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Synthesis of novel N2-adamantyl derivatives of 2-amino-6-methyl-4(3H)-pyrimidinone as potential activators of tumor necrosis factor (TNF) release

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A method has been developed for the synthesis of N2-adamantyl-2-amino-6-methyl-4(3H)-pyrimidinones based on the reaction of (adamant-1-yl)alkylamine with 2-(ethylsulfanyl)-6-methyl-4(3H)-pyrimidinone which can lead to the corresponding derivatives in which the exocyclic nitrogen atom and the adamantyl radical are separated by a hydrocarbon fragment.

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Authors and Affiliations

  1. Volgograd State Technical University, Volgograd, 400131, Russia

    I. A. Novakov, B. S. Orlinson, R. V. Brunilin, M. B. Nawrozkij, E. N. Savel’ev & G. A. Novikova

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  1. I. A. Novakov
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  2. B. S. Orlinson
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  3. R. V. Brunilin
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  4. M. B. Nawrozkij
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  5. E. N. Savel’ev
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  6. G. A. Novikova
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1541–1544, October, 2006.

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Novakov, I.A., Orlinson, B.S., Brunilin, R.V. et al. Synthesis of novel N2-adamantyl derivatives of 2-amino-6-methyl-4(3H)-pyrimidinone as potential activators of tumor necrosis factor (TNF) release. Chem Heterocycl Compd 42, 1331–1333 (2006). https://doi.org/10.1007/s10593-006-0243-7

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  • DOI: https://doi.org/10.1007/s10593-006-0243-7

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