Abstract
3-Cyano-3-hetaryl-2-oxopropyl-and 3-cyano-3-hetaryl-1-methyl-2-oxopropyl ethanethioates were obtained by the acylation of 2-azahetarylacetonitriles with (acetylthio)acetyl and α-(acetylthio)propionyl chlorides respectively. They are deacetylated by the action of amines and undergo cyclization with the formation of 5-amino-4-hetarylthiophen-2(2H)-ones.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1314–1319, September, 2006.
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Volovenko, Y.M., Volovnenko, T.A. & Dobrydnev, A.V. Acylation of 2-azahetarylacetonitriles with (acetylthio)acetyl and α-(acetylthio)-propionyl chlorides. Production of 5-amino-4-hetarylthiophen-3(2H)-ones. Chem Heterocycl Compd 42, 1137–1142 (2006). https://doi.org/10.1007/s10593-006-0217-9
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DOI: https://doi.org/10.1007/s10593-006-0217-9