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Chemistry of Heterocyclic Compounds

, Volume 42, Issue 7, pp 882–885 | Cite as

4-Hydroxy-2-quinolones. 97. Simple synthesis of the esters of 4-halo-substituted 2-oxo-1,2-dihydroquinoline-3-carboxylic acids

  • I. V. Ukrainets
  • L. V. Sidorenko
  • O. V. Gorokhova
  • S. V. Slobodzyan
Article

Abstract

Short term treatment of 3-ethoxycarbonyl-4-morpholino-2-oxo-1,2-dihydroquinoline with aqueous solutions of hydrohalogen acids leads to the formation of the ethyl esters of 4-halo-substituted 2-oxo-1,2-dihydroquinoline-3-carboxylic acids. Hydrolysis in HF is possible on extended boiling only to the 4-hydroxy derivative.

Keywords

4-amino-2-oxo-1,2-dihydroquinolines enamines ethyl esters of 4-halo-2-oxo-1,2-dihydroquinoline-3-carboxylic acids hydrolysis decarboxylation 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • I. V. Ukrainets
    • 1
  • L. V. Sidorenko
    • 1
  • O. V. Gorokhova
    • 1
  • S. V. Slobodzyan
    • 2
  1. 1.National Pharmaceutical UniversityKharkivUkraine
  2. 2.Ohio Northern UniversityAdaUSA

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