Selective hydrogenolysis of benzyl-protected 1-hydroxy-3-hydroxyimino-2-pyrrolidinones
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On hydrogenolysis of 1-benzyloxy-3-benzyloxyimino-2-pyrrolidinones in the presence of 10% Pd/C selective removal occurs of the O-benzyl (Bn) protection of the hydroxamic acid, with retention of the double bond and benzyl protection of the oxime group. The yields of reaction products were 66–98%.
Keywordsα-oxyiminohydroxamic acids 2-pyrrolidinone derivatives hydrogenolysis
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