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Chemistry of Heterocyclic Compounds

, Volume 42, Issue 6, pp 776–781 | Cite as

4-hydroxy-2-quinolones. 96. Synthesis and properties of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

  • I. V. Ukrainets
  • L. V. Sidorenko
  • O. V. Gorokhova
  • S. V. Shishkina
Article

Abstract

Alkaline hydrolysis of the ethyl ester of 4-(cyanoethoxycarbonylmethyl)-2-oxo-1,2-dihydroquinoline-3-carboxylic acid is accompanied by decarboxylation with loss of two molecules of CO2 and leads to 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid.

Keywords

4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid cyanoacetic ester, 4-chloroquinoline amidation hydrolysis decarboxylation X-ray structural analysis 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • I. V. Ukrainets
    • 1
  • L. V. Sidorenko
    • 1
  • O. V. Gorokhova
    • 1
  • S. V. Shishkina
    • 2
  1. 1.National Pharmaceutical UniversityKharkovUkraine
  2. 2.Institute of Scintillation CompoundsNational Academy of Sciences of UkraineKharkov

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