Advertisement

Chemistry of Heterocyclic Compounds

, Volume 42, Issue 6, pp 765–775 | Cite as

4-hydroxy-2-quinolones. 95. Synthesis, structure, and antitubercular properties of hetarylamides of 4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid

  • I. V. Ukrainets
  • E. V. Kolesnik
  • L. V. Sidorenko
  • O. V. Gorokhova
  • A. V. Turov
Article

Abstract

The optimal conditions for obtaining hetarylamides of 4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid are suggested on the basis of derivatographic investigations. The 1H NMR spectra of the synthesized compounds, their spatial structure, and also the results of a study of their antitubercular properties are discussed.

Keywords

amides 4-hydroxy-2-oxoquinoline-3-carboxylic acids antitubercular activity X-ray structural analysis thermolysis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    I. V. Ukrainets, L. V. Sidorenko, O. V. Gorokhova, and O. V. Shishkin, Khim. Geterotsikl. Soedin., 718 (2006).Google Scholar
  2. 2.
    A. G. Khomenko, Probl. Tuberkuleza, No. 2, 2 (1994).Google Scholar
  3. 3.
    A. G. Khomenko, Probl. Tuberkuleza, No. 1, 4 (1995).Google Scholar
  4. 4.
    I. V. Ukrainets, Abdel Naser Kh. N. Dakkakh, P. A. Bezuglyi, O. V. Gorokhova, L. V. Sidorenko, and T. V. Alekseeva, Vestn. Farm., No. 1(25), 9 (2001).Google Scholar
  5. 5.
    I. V. Ukrainets, M. Amer, P. A. Bezugly, O. V. Gorokhova, L. V. Sidorenko, and A. V. Turov, Khim. Geterotsikl. Soedin., 654 (2002).Google Scholar
  6. 6.
    I. V. Ukrainets, Amzhad Abu Sharekh, P. A. Bezuglyi, L. V. Sidorenko, and O. V. Gorokhova, Farm. Zh., No. 5, 52 (2002).Google Scholar
  7. 7.
    I. V. Ukrainets, S. A. El Kayal, O. V. Gorokhova, L. V. Sidorenko, and T. V. Alekseeva, Vestn. Farm., No. 1(37), 12 (2004).Google Scholar
  8. 8.
    I. V. Ukrainets, O. S. Prokopenko, L. V. Sidorenko, and O. V. Gorokhova, Vestn. Farm., No. 3(39), 3 (2004).Google Scholar
  9. 9.
    I. V. Ukrainets, E. A. Taran, O. V. Shishkin, O. V. Gorokhova, S. G. Taran, Jaradat Nidal Amin, and A. V. Turov, Khim. Geterotsikl. Soedin., 516 (2000).Google Scholar
  10. 10.
    H. Gunther, NMR Spectroscopy: Basic Principles, Concepts, and Applications in Chemistry, John Wiley & Sons, Chichester (1995).Google Scholar
  11. 11.
    I. V. Ukrainets, L. V. Sidorenko, O. V. Gorokhova, V. B. Rybakov, V. V. Chernishev, and E. V. Kolesnik, Vestn. Farm., No. 2(38), 7 (2004).Google Scholar
  12. 12.
    Yu. V. Zefirov and P. M. Zorkii, Usp. Khim., 58, 713 (1989).Google Scholar
  13. 13.
    H.-B. Burgi and J. D. Dunitz, Structure Correlation, Vol. 2, VCH, Weinheim (1994), p. 741.Google Scholar
  14. 14.
    S. H. Siddiqui in H. D. Isenberg (editor), Clinical Microbiology Procedures Handbook, Vol. 1, American Society for Microbiology, Washington D. C. (1992), p. 5.14.2.Google Scholar
  15. 15.
    G. M. Sheldrick, SHELX97. PC Version. A System of Computer Programs for Crystal Structure Solution and Refinement, Rev. 2, (1998).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • I. V. Ukrainets
    • 1
  • E. V. Kolesnik
    • 1
  • L. V. Sidorenko
    • 1
  • O. V. Gorokhova
    • 1
  • A. V. Turov
    • 2
  1. 1.National Pharmaceutical UniversityKharkovUkraine
  2. 2.Kiev Taras Shevchenko National UniversityKievUkraine

Personalised recommendations