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Chemistry of Heterocyclic Compounds

, Volume 42, Issue 6, pp 761–764 | Cite as

Cytotoxicity of metal 8-quinolinethiolates

  • E. Lukevics
  • I. Shestakova
  • I. Domracheva
  • A. Nesterova
  • D. Zaruma
  • J. Ashaks
Article

Abstract

High cytotoxicity has been established for the 8-quinolinethiolates of copper, cadmium, indium, antimony, bismuth, ruthenium, rhodium, palladium, osmium, iridium, and platinum on HT-1080 (human fibrosarcoma), MG-22A (mouse hepatoma), and B-16 (mouse melanoma) tumor cells. The greatest activity against HT-1080 was possessed by the iridium complex, and against MG-22A by the osmium complex. All the investigated metal 8-quinolinethiolates were highly toxic in relation to NIH 3T3 normal mouse embryo fibroblasts.

Keywords

8-quinolinethiolates of metals cytotoxicity 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • E. Lukevics
    • 1
  • I. Shestakova
    • 1
  • I. Domracheva
    • 1
  • A. Nesterova
    • 1
  • D. Zaruma
    • 2
  • J. Ashaks
    • 2
  1. 1.1 Latvian Institute of Organic ChemistryRiga
  2. 2.Institute of Inorganic ChemistryRiga Technical UniversitySalaspilsLatvia

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