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Cytotoxicity of metal 8-quinolinethiolates

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

High cytotoxicity has been established for the 8-quinolinethiolates of copper, cadmium, indium, antimony, bismuth, ruthenium, rhodium, palladium, osmium, iridium, and platinum on HT-1080 (human fibrosarcoma), MG-22A (mouse hepatoma), and B-16 (mouse melanoma) tumor cells. The greatest activity against HT-1080 was possessed by the iridium complex, and against MG-22A by the osmium complex. All the investigated metal 8-quinolinethiolates were highly toxic in relation to NIH 3T3 normal mouse embryo fibroblasts.

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Authors and Affiliations

  1. 1 Latvian Institute of Organic Chemistry, Riga, LV-1006

    E. Lukevics, I. Shestakova, I. Domracheva & A. Nesterova

  2. Institute of Inorganic Chemistry, Riga Technical University, Salaspils, LV-2169, Latvia

    D. Zaruma & J. Ashaks

Authors
  1. E. Lukevics
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  2. I. Shestakova
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  3. I. Domracheva
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  4. A. Nesterova
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  5. D. Zaruma
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  6. J. Ashaks
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 870–873, June, 2006.

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Lukevics, E., Shestakova, I., Domracheva, I. et al. Cytotoxicity of metal 8-quinolinethiolates. Chem Heterocycl Compd 42, 761–764 (2006). https://doi.org/10.1007/s10593-006-0158-3

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  • DOI: https://doi.org/10.1007/s10593-006-0158-3

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