Chemistry of Heterocyclic Compounds

, Volume 42, Issue 6, pp 753–760 | Cite as

Cyclization products of N-fluorophenyl-β-alanines and their properties

  • R. Vaickelioniene
  • V. Mickevicius


Interaction of 2-and 4-fluorophenylamines with acrylic and itaconic acids leads to the synthesis of the corresponding N-substituted β-alanines, the cyclization of which leads to derivatives of dihydropyrimidinone, 4-carboxy-2-pyrrolidinone, and tetrahydropyridone. Compounds having benzimidazole, pyrazole, and hydrazine fragments in the molecule have been obtained from 4-carboxy-1-(4-fluorophenyl)-2-pyrrolidinone.


dihydropyrimidinones N-substituted β-alanines 4-carboxy-2-pyrrolidinones tetrahydropyridone condensation 


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • R. Vaickelioniene
    • 1
  • V. Mickevicius
    • 1
  1. 1.Kaunas University of TechnologyKaunasLithuania

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