Abstract
Interaction of 2-and 4-fluorophenylamines with acrylic and itaconic acids leads to the synthesis of the corresponding N-substituted β-alanines, the cyclization of which leads to derivatives of dihydropyrimidinone, 4-carboxy-2-pyrrolidinone, and tetrahydropyridone. Compounds having benzimidazole, pyrazole, and hydrazine fragments in the molecule have been obtained from 4-carboxy-1-(4-fluorophenyl)-2-pyrrolidinone.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
V. Mickevicius and A. Patupaite, Khim. Geterotsikl. Soedin., 951 (2000).
M. Mickevicius, V. Mickevicius, and R. Vaickelioniene, Khim. Geterotsikl. Soedin., 911 (2004).
M. Nogrady, Stereochemistry: Basic Ideas and Applications [Russian translation], Mir, Moscow (1984), 391 pp.
G. Bradley, J. Clark, and W. Kernick, J. Chem. Soc., Perkin Trans. 1, 2019 (1972).
Author information
Authors and Affiliations
Additional information
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 862–869, June, 2006.
Rights and permissions
About this article
Cite this article
Vaickelioniene, R., Mickevicius, V. Cyclization products of N-fluorophenyl-β-alanines and their properties. Chem Heterocycl Compd 42, 753–760 (2006). https://doi.org/10.1007/s10593-006-0157-4
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10593-006-0157-4