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Chemistry of Heterocyclic Compounds

, Volume 42, Issue 6, pp 726–731 | Cite as

Efficient synthesis of benzimidazolyl-phenoxyacetic acid O-acetylxylopyranosyl and O-acetylgalactopyranosyl esters and their antiviral activity

  • H. Chen
  • W. Song
  • S. Huang
Article

Abstract

Six benzimidazolylphenoxyacetic acid O-acetylxylopyranosyl and O-acetylgalactopyranosyl esters were synthesized through esterification reactions at room temperature using 4-dimethylaminopyridine as a catalyst and triethylamine as a deacidification reagent. Their structure was confirmed by IR, 1H NMR spectra, MS, and elemental analysis. The synthesized compounds are all of β-configuration. The results show that DMAP is an effective catalyst; the yields can reach 63.6%. The above esters showed improved antiviral activity against tobacco mosaic virus.

Keywords

O-acetylgalactopyranosyl esters O-acetylxylopyranosyl esters benzimidazolyl-phenoxyacetic acid esters tobacco mosaic virus DMAP/Et3

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • H. Chen
    • 1
  • W. Song
    • 1
  • S. Huang
    • 1
  1. 1.Department of Applied ChemistryGuangdong Ocean UniversityZhanjiangP. R. China

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