Efficient synthesis of benzimidazolyl-phenoxyacetic acid O-acetylxylopyranosyl and O-acetylgalactopyranosyl esters and their antiviral activity
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Six benzimidazolylphenoxyacetic acid O-acetylxylopyranosyl and O-acetylgalactopyranosyl esters were synthesized through esterification reactions at room temperature using 4-dimethylaminopyridine as a catalyst and triethylamine as a deacidification reagent. Their structure was confirmed by IR, 1H NMR spectra, MS, and elemental analysis. The synthesized compounds are all of β-configuration. The results show that DMAP is an effective catalyst; the yields can reach 63.6%. The above esters showed improved antiviral activity against tobacco mosaic virus.
KeywordsO-acetylgalactopyranosyl esters O-acetylxylopyranosyl esters benzimidazolyl-phenoxyacetic acid esters tobacco mosaic virus DMAP/Et3N
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