Skip to main content
SpringerLink
Log in

Synthesis of new α-spiroheteryl-fused butanolides

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

Abstract

4-Alkoxymethyl-2-bromo-2-ethoxycarbonylbutanolides were obtained with good yields by the bromination of 4-alkoxymethyl-2-ethoxycarbonylbutanolides with bromine in dry carbon tetrachloride. Reaction of the products with thiourea and aryl-substituted thioureas gave spiroheteryl-fused lactones of a new generation-8-alkoxymethyl-3-amino(arylamino)-7-oxa-4-thia-2-azaspiro[4,4]-2-nonene-1,6-diones.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. Richard, C. Marcello de Moura, and L. Kenneth, J. Am. Chem. Soc., 75, 1044 (1953).

    Article  Google Scholar 

  2. V. Zebic, V. Skaric, Z. Ruzic-Toros, and B. Kojic-Prodic, Croat. Chem. Acta, 59, 491 (1986).

    Google Scholar 

  3. V. S. Arutyunyan, T. V. Kochikyan, Z. Yu. Nalbandyan, M. A. Samvelyan, and A. A. Avetisyan, Zh. Org. Khim., 37, 119 (2001).

    Google Scholar 

  4. D. F. Dickel and G. De Stevans, US Patent 3528223; Chem. Abstr., 74, 22694 (1971).

    Google Scholar 

  5. D. F. Dickel and G. De Stevans, US Patent 3686211; Chem. Abstr., 77, 151925 (1972).

    Google Scholar 

  6. V. S. Arutyunyan, T. V. Kochikyan, T. V. Kochikyan, L. I. Bugaeva, and M. G. Antadze, Arm. Khim. Zh., 38, 688 (1985).

    CAS  Google Scholar 

  7. V. S. Arutyunyan, T. V. Kochikyan, A. A. Avetisyan, and I. G. Korpakova, Armenian Patent 1114, Ofits. Byul. Promyshlennoi Sobstvennosti, 1 (2002).

  8. I. M. Gella, L. Yu. Sernienko, and A. N. Cherevko, Khim.-Farm. Zh., 24, 29 (1990).

    CAS  Google Scholar 

  9. H. Ferai, M. Craire, A. Rondot, A. Aumelas, and G. Aizou, J. Chem. Soc, Perkin Trans. 2, 3045 (1990).

  10. H. Avchibasi, H. Anil, and M. Toprak, Phytochemistry, 26, 2852 (1987).

    Article  Google Scholar 

  11. H. Itakava, H. Morita, K. Osawa, K. Watanabe, and Y. Itaka, Chem. Pharm. Bull., 35, 2849 (1987).

    Google Scholar 

  12. V. S. Arutyunyan, T. V. Kochikyan, N. S. Egiazaryan, and A. A. Avetisyan, Arm. Khim. Zh., 47, 91 (1994).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Organic Chemistry, Erevan State University, Erevan, 375049, Republic of Armenia

    T. V. Kochikyan, M. A. Samvelyan, V. S. Harutyunyan & A. A. Avetisyan

Authors
  1. T. V. Kochikyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. A. Samvelyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. S. Harutyunyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. A. Avetisyan
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 510–514, April, 2006.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kochikyan, T.V., Samvelyan, M.A., Harutyunyan, V.S. et al. Synthesis of new α-spiroheteryl-fused butanolides. Chem Heterocycl Compd 42, 446–450 (2006). https://doi.org/10.1007/s10593-006-0109-z

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10593-006-0109-z

Keywords

Search

Navigation