Advertisement

Chemistry of Heterocyclic Compounds

, Volume 42, Issue 3, pp 389–391 | Cite as

Synthesis of azinylthioureas and their heterocyclization using α-chloroacetoacetic ester

  • V. V. Dovlatyan
  • K. A. Eliazyan
  • E. A. Ghazaryan
  • A. P. Yengoyan
Article

Abstract

Treatment of aminopyrimidines with a mixture of PhCOCl and NH4SCN and subsequent debenzoylation of the N-benzoyl-N′-(4,6-substituted pyrimidin-2-yl)thioureas obtained gave pyrimidinyl-2-thioureas. The heterocyclization of the azinyl-2-thioureas with α-chloroacetoacetic ester gave ethyl 2-(4,6-substituted azin-2-yl)aminothiazole-5-carboxylates.

Keywords

azinylthioureas thiazole-5-carboxylic acid heterocyclization 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Y. Sawwa and R. Maeda, J. Pharm. Soc. Jpn., 76, 301 (1956); Chem. Abstr., 50, 13875 (1956).Google Scholar
  2. 2.
    I. K. Moiseev, M. N. Zemtsova, and N. V. Makarova, Khim. Geterotsikl. Soedin., 876 (1994).Google Scholar
  3. 3.
    R. Elderfield (editor), Heterocyclic Compounds [Russian translation], Vol. 6, Inostr. Lit. Publishing House, Moscow (1960), p. 402.Google Scholar
  4. 4.
    N. N. Mel’nikov, The Chemistry and Technology of Pesticides [in Russian], Khimiya, Moscow (1974), p. 629.Google Scholar
  5. 5.
    L. A. Khachatryan, Dissertations of Candidates in Chemical Sciences, Yerevan (1983).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • V. V. Dovlatyan
    • 1
  • K. A. Eliazyan
    • 1
  • E. A. Ghazaryan
    • 1
  • A. P. Yengoyan
    • 1
  1. 1.Armenian Agricultural AcademyYerevan

Personalised recommendations