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4-Hydroxy-2-quinolones. 92. Reaction of 1-R-4-chloro-3-ethoxycarbonyl-2-oxo-1,2-dihydroquinolines with anilines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A preparative method is proposed and the synthesis of 4-arylamino-2-oxo-1,2-dihydroquinolines has been effected. An X-ray structural investigation of 4-(4-chlorophenylamino)-2-oxo-1-propyl-1,2-dihydroquinoline-3-carboxylic acid has been carried out enabling the ease of decarboxylating such compounds to be substantiated. Results are given of a study of the anti-inflammatory activity of the synthesized compounds.

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Authors and Affiliations

  1. National Pharmaceutical University, Kharkov, 61002, Ukraine

    I. V. Ukrainets, L. V. Sidorenko & O. V. Gorokhova

  2. An-Najah National University College of Pharmacy, P.O. Box 7, Nablus, Palestine

    N. A. Jaradat

Authors
  1. I. V. Ukrainets
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  2. L. V. Sidorenko
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  3. O. V. Gorokhova
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  4. N. A. Jaradat
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 386–395, March, 2006.

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Ukrainets, I.V., Sidorenko, L.V., Gorokhova, O.V. et al. 4-Hydroxy-2-quinolones. 92. Reaction of 1-R-4-chloro-3-ethoxycarbonyl-2-oxo-1,2-dihydroquinolines with anilines. Chem Heterocycl Compd 42, 343–351 (2006). https://doi.org/10.1007/s10593-006-0091-5

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  • DOI: https://doi.org/10.1007/s10593-006-0091-5

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