Chemistry of Heterocyclic Compounds

, Volume 42, Issue 1, pp 64–69 | Cite as

4-Hydroxy-2-quinolones. 90. Synthesis and antitubercular activity of 4-methyl-2-thiazolylamides of halo-substituted 4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylic acids

  • I. V. Ukrainets
  • L. V. Sidorenko
  • L. A. Petrushova
  • O. V. Gorokhova


Several variants were studied for the synthesis of esters of halogen derivatives of 4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylic acids, whose reaction with 2-amino-4-methylthiazole gives the corresponding hetarylamides. Results are given for a study of the antitubercular activity of these products.


amides 2-amino-4-methylthiazole 4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylic acids antitubercular activity 


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • I. V. Ukrainets
    • 1
  • L. V. Sidorenko
    • 1
  • L. A. Petrushova
    • 1
  • O. V. Gorokhova
    • 1
  1. 1.National Pharmaceutical UniversityKharkovUkraine

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