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Chemistry of Heterocyclic Compounds

, Volume 42, Issue 1, pp 64–69 | Cite as

4-Hydroxy-2-quinolones. 90. Synthesis and antitubercular activity of 4-methyl-2-thiazolylamides of halo-substituted 4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylic acids

  • I. V. Ukrainets
  • L. V. Sidorenko
  • L. A. Petrushova
  • O. V. Gorokhova
Article

Abstract

Several variants were studied for the synthesis of esters of halogen derivatives of 4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylic acids, whose reaction with 2-amino-4-methylthiazole gives the corresponding hetarylamides. Results are given for a study of the antitubercular activity of these products.

Keywords

amides 2-amino-4-methylthiazole 4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylic acids antitubercular activity 

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References

  1. 1.
    I. V. Ukrainets, L. A. Petrushova, L. V. Sidorenko, V. B. Rybakov, and V. V. Chernyshev, Zh. Org. Pharm. Khim., 2, No. 3(7), 26 (2004).Google Scholar
  2. 2.
    E. Rubinstein, Chemotherapy, 47, 3 (2001).Google Scholar
  3. 3.
    G. A. Mokrushina, V. N. Charushin, and O. N. Chupakhin, Khim.-farm. Zh., 29, No. 9, 5 (1995).Google Scholar
  4. 4.
    P. C. Hannan and R. F. Goodwin, Res. Vet. Sci., 49, 203 (1990).Google Scholar
  5. 5.
    P. Grohs, S. Houssaye, A. Aubert, L. Gutmann, and E. Varon, Antimicrob. Agents Chemother., 47, 3542 (2003).Google Scholar
  6. 6.
    I. V. Ukrainets, I. V. Gorlacheva, O. V. Gorokhova, P. A. Bezuglyi, and L. V. Sidorenko, Farm. Zh., No. 1, 75 (2000).Google Scholar
  7. 7.
    I. V. Ukrainets, O. V. Gorokhova, S. G. Taran, P. A. Bezuglyi, A. V. Turov, I. A. Marusenko, and O. A. Evtifeeva, Khim. Geterotsikl. Soedin., 958 (1994).Google Scholar
  8. 8.
    L. Collins and S. G. Franzblau, Antimicrob. Agents. Chemother., 41, 1004 (1997).Google Scholar
  9. 9.
    S. H. Siddiqui, in: H. D. Isenberg (editor), Clinical Microbiology Procedures Handbook, American Society for Microbiology, Washington, D. C., Vol. 1 (1992), p. 5.14.2.Google Scholar
  10. 10.
    L. B. Heifets, in: L. B. Heifets (editor), Drug Susceptibility in the Chemotherapy of Mycobacterial Infections, CRC Press, Boca Raton (1991), p. 89.Google Scholar
  11. 11.
    C. B. Inderleid and K. A. Nash, in: V. Lorian (editor), Antibiotics in Laboratory Medicine, Williams and Wilkins, Baltimore (1996), p. 127.Google Scholar
  12. 12.
    I. V. Ukrainets, E. A. Taran, O. V. Shishkin, O. V. Gorokhova, S. G. Taran, Nidal Amin Jaradat, and A. V. Turov, Khim. Geterotsikl. Soedin., 516 (2000).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • I. V. Ukrainets
    • 1
  • L. V. Sidorenko
    • 1
  • L. A. Petrushova
    • 1
  • O. V. Gorokhova
    • 1
  1. 1.National Pharmaceutical UniversityKharkovUkraine

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