Skip to main content
Log in

Hydrolysis of 7,7-Substituted Derivatives of 3-tert-Butyl-3,4-dihydro-2H-thiazolo-[3,2-a][1,3,5]triazin-6(7H)-one

Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Alkaline hydrolysis of 3-tert-butyl-7,7-bis(hydroxymethyl)-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]-triazin-6(7H)-one can occur in three directions: with cleavage of the tetrahydrotriazine ring, with cleavage of the thiazolidine ring, and also with opening of both rings. Depending on the process conditions, either the hydrolysis product corresponding to the first direction or the hydrolytic decomposition products corresponding to the second and third directions can be obtained in preparative quantities. Hydrolysis of 3,3′-di-tert-butyl-3′,4′-dihydro-2′ H-spiro[(perhydro-1,3-oxazine)-5,7′-thiazolo[3,2-a][1,3,5]triazin]-6′-one in (NH4)2CO3 solution occurs in two steps: in the first step, cleavage of the tetrahydrotriazine ring occurs; and in the second step, opening of the perhydrooxazine ring occurs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. F. C. Brown, Chem. Rev., 61, 463 (1961).

    Article  Google Scholar 

  2. S. M. Ramsh and A. G. Ivanenko, Khim. Geterotsikl. Soedin., 1743 (2003).

  3. S. Yu. Solov'eva, S. M. Ramsh, and A. I. Ginak, Khim. Geterotsikl. Soedin., 1204 (1983)

  4. S. M. Ramsh, T. S. Basieva, O. Yu. Uryupov, S. Yu. Solov'eva, V. M. Vinogradov, A. I. Ginak, B. I. Krivoruchko, I. A. Shelkovnikov, and Yu. N. Shanin, USSR Inventor's Certificate 1095612; B. I., No. 20, 197 (1984).

  5. V. M. Fedoseev, A. A. Mandrugin, and M. N. Semenenko, Khim. Geterotsikl. Soedin., 44 (1984).

  6. H. Aspelund, Acta Acad. Aboensis (Math. Phys.), No. 1, 1 (1964).

  7. H. Aspelund, Acta Acad. Aboensis (Math. Phys.), No. 2, 1 (1964).

  8. S. M. Ramsh, N. A. Smorygo, and A. I. Ginak, Khim. Geterotsikl. Soedin., 1066 (1984).

Download references

Author information

Authors and Affiliations

Authors

Additional information

__________

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1089–1097, July, 2005.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ramsh, S.M., Ivanenko, A.G., Shpilevyi, V.A. et al. Hydrolysis of 7,7-Substituted Derivatives of 3-tert-Butyl-3,4-dihydro-2H-thiazolo-[3,2-a][1,3,5]triazin-6(7H)-one. Chem Heterocycl Compd 41, 921–928 (2005). https://doi.org/10.1007/s10593-005-0249-6

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10593-005-0249-6

Keywords

Navigation