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Reaction Of 3-Nitro-1,2,4-triazolederivatives with Alkylating Agents. 1. Alkylation in the Presence of Alkali

Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Alkylation of 3-nitro-1,2,4-triazole and 5-methyl-3-nitro-1,2,4-triazole with dialkyl sulfates or alkyl halides in the presence of alkali proceeds with a low selectivity for the alkylating agent with the formation of two regioisomers at the N(1) and N(2) atoms of the heterocycle. Depending on the reaction conditions the proportion of the N(2) isomer was 14.6-33.8%.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1020–1025, July, 2005.

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Sukhanov, G.T., Lukin, A.Y. Reaction Of 3-Nitro-1,2,4-triazolederivatives with Alkylating Agents. 1. Alkylation in the Presence of Alkali. Chem Heterocycl Compd 41, 861–865 (2005). https://doi.org/10.1007/s10593-005-0239-8

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  • DOI: https://doi.org/10.1007/s10593-005-0239-8

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