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Studies on Pyrazine Derivatives. 39. Synthesis, Reactions, and Tuberculostatic Activity of 3-Pyrazinyl-1,2,4-triazolo[4,3-a]-1,3-diazacycloalkanes

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

In the reactions of S,S′-dimethyldithiocarbamate pyrazinoylhydrazone with diamines some 3-pyrazinyl-1,2,4-triazolo[4,3-a]-1,3-diazacycloalkanes were obtained, and the mechanism of their formation was proposed. The products were acylated, hydroxyalkylated, and aminomethylated. Their tuberculostatic activity was tested in vitro.

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Authors and Affiliations

  1. Departament of Organic Chemistry, Medical University of Gdansk, 80-416, Gdansk, Poland

    M. Sitarz & H. Foks

  2. Departament of Microbiology, Institute of Tuberculosis and Pulmonary Diseases, 01-138, Warszawa, Poland

    M. Janowiec, Z. Zwolska & E. Augustynowicz-Kopec

Authors
  1. M. Sitarz
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  2. H. Foks
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  3. M. Janowiec
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  4. Z. Zwolska
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  5. E. Augustynowicz-Kopec
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__________

Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 230–237, February, 2005.

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Sitarz, M., Foks, H., Janowiec, M. et al. Studies on Pyrazine Derivatives. 39. Synthesis, Reactions, and Tuberculostatic Activity of 3-Pyrazinyl-1,2,4-triazolo[4,3-a]-1,3-diazacycloalkanes. Chem Heterocycl Compd 41, 200–207 (2005). https://doi.org/10.1007/s10593-005-0128-1

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  • DOI: https://doi.org/10.1007/s10593-005-0128-1

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