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Synthesis and structural determination of 5-arylamino-1,3-dimethylpyrazoles

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Treatment of 4-arylamino-4-thioxo-2-butanones with methylhydrazine in acetic acid gives 5-arylamino-1,3-dimethylpyrazoles which are readily halogenated in the 4 position. The thermal decomposition of 3-anilino-1,2,5-trimethyl-1H-pyrazolium chloride gives 1,3-dimethyl-5-phenylaminopyrazole and 1,5-dimethyl-3-phenylaminopyrazole in the approximate ratio of 1:1.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Ukraine National Academy of Sciences, Kiev, 02094

    V. N. Britsun, I. M. Bazavova, V. N. Bodnar, A. N. Chernega & M. O. Lozinskii

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  1. V. N. Britsun
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  2. I. M. Bazavova
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  3. V. N. Bodnar
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  4. A. N. Chernega
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  5. M. O. Lozinskii
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 120–126, January, 2005.

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Britsun, V.N., Bazavova, I.M., Bodnar, V.N. et al. Synthesis and structural determination of 5-arylamino-1,3-dimethylpyrazoles. Chem Heterocycl Compd 41, 105–110 (2005). https://doi.org/10.1007/s10593-005-0115-6

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  • DOI: https://doi.org/10.1007/s10593-005-0115-6

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