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Preparation of 1-amino-4-methylpiperazine

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The selectivity of the formation of N-di(2-chloroethyl)methylamine in reactions with various chlorinating agents has been investigated and the optimum chlorinating agent has been found. 1-Amino-4-methylpiperazine has been obtained for the first time by the cyclization of N-di(2-chloroethyl)methylamine with aqueous hydrazine. A possible mechanism has been proposed for the cyclization reaction.

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Authors and Affiliations

  1. Saint-Petersburg State Technical University, 190013, Saint-Petersburg, Russia

    P. M. Kushakova, V. A. Kuznetsov & A. V. Garabadgiu

  2. “Olainfarm”, LV-2114, Riga, Latvia

    A. N. Chernobroviy

Authors
  1. P. M. Kushakova
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  2. A. N. Chernobroviy
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  3. V. A. Kuznetsov
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  4. A. V. Garabadgiu
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1794–1797, December, 2004.

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Kushakova, P.M., Chernobroviy, A.N., Kuznetsov, V.A. et al. Preparation of 1-amino-4-methylpiperazine. Chem Heterocycl Compd 40, 1546–1549 (2004). https://doi.org/10.1007/s10593-005-0097-4

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  • DOI: https://doi.org/10.1007/s10593-005-0097-4

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