Abstracts from the EACR seed and soil: in vivo models of metastasis conference
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Proffered Paper 1: Modulation of the pre-metastatic lymph node niche by melanoma cells through secreted exosomes
Susana García-Silva3, Alberto Benito-Martin1, Laura Nogues-Vera1, Alberto Hernández-Barranco3, Ana Isabel Amor3, Cristina Merino3, Marina Mazariegos3, Irina Matei1, Raghu Kataru2, Osvaldo Graña3, Marta Hergueta-Redondo3, Mary Sue Brady2, Babak Mehrara2, David Lyden1, Héctor Peinado1,3
1Department of Pediatrics, Drukier Institute for Children’s Health and Meyer Cancer Center, Weill Cornell Medical College, New York, USA, 2Memorial Sloan Kettering Cancer Center, New York, USA, 3Microenvironment and Metastasis Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
Metastasis is considered the most devastating step in cancer progression, being responsible of 90% of all cancer deaths. Lymph nodes adjacent to the primary tumor are often the first site of metastases. It has been demonstrated that tumor cells induce early changes in the...