Clinical & Experimental Metastasis

, Volume 32, Issue 2, pp 135–141 | Cite as

Bladder metastasis from renal cell carcinoma: retrospective analysis of 65 reported cases

  • Kazuhiro Matsumoto
  • Nozomi Hayakawa
  • So Nakamura
  • Mototsugu Oya
Research Paper


This study was carried out to clarify the presentation, treatment options, and prognosis of renal cell carcinoma (RCC) metastasis to the bladder in which we do not yet have a comprehensive understanding. A systematic Medline, Web of Science, Embase, Google, and Ichushi Web search was performed to identify articles describing RCC metastasis to the bladder. The final cohort included 65 patients. The majority (75 %) experienced gross hematuria at the point of diagnosis of RCC. RCC metastasis to the bladder occurred both synchronously (23 %) and metachronously (77 %), and the median time for metachronous bladder metastasis following the diagnosis of RCC was 33 months. Of the 58 patients whose metastatic data were available, 36 (62 %) had metastasis to the bladder only, while 22 (38 %) had additional sites of metastasis. On pathology, clear cell carcinoma was the most common histology (92 %) and all bladder tumors were consistent with RCC metastasis; the median tumor size was 2.1 cm, and two-thirds of cases were superficial (non-muscle invasive) disease. The 2-year cancer-specific survival rate in patients with solitary bladder metastasis was 71.1 %, which was significantly higher than in patients with additional distant metastasis (25.8 %, p = 0.007). Regarding the interval after the diagnosis of primary RCC, the 2-year cancer-specific survival rate in patients who experienced bladder metastasis after more than a 1 year follow-up was 58.4 %, compared to 34.6 % in their counterparts (p = 0.063). A curative resection may provide a good possibility of long-term survival, particularly in those with a solitary bladder metastasis and/or a long interval after nephrectomy.


Bladder metastasis Renal cell carcinoma RCC Kidney cancer Metastatic tumor 



Renal cell carcinoma


Cancer-specific survival


Hazard ratio


Confidence interval



This study was performed as a research program of the Project for Development of Innovative Research on Cancer Therapeutics (P-Direct), Ministry of Education, Culture, Sports, Science and Technology of Japan.


  1. 1.
    Hock LM, Lynch J, Balaji KC (2002) Increasing incidence of all stages of kidney cancer in the last 2 decades in the United States: an analysis of surveillance, epidemiology and end results program data. J Urol 167(1):57–60. doi: 10.1016/S0022-5347(05)65382-7 PubMedCrossRefGoogle Scholar
  2. 2.
    Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, Leibovich BC, Zincke H (2003) A multifactorial postoperative surveillance model for patients with surgically treated clear cell renal cell carcinoma. J Urol 170(6 Pt 1):2225–2232. doi: 10.1097/01.ju.0000095541.10333.a7 PubMedCrossRefGoogle Scholar
  3. 3.
    Pagano S, Franzoso F, Ruggeri P (1996) Renal cell carcinoma metastases. Review of unusual clinical metastases, metastatic modes and patterns and comparison between clinical and autopsy metastatic series. Scand J Urol Nephrol 30(3):165–172. doi: 10.3109/00365599609181294 PubMedCrossRefGoogle Scholar
  4. 4.
    Saitoh H (1981) Distant metastasis of renal adenocarcinoma. Cancer 48(6):1487–1491PubMedCrossRefGoogle Scholar
  5. 5.
    Mazumdar M, Glassman JR (2000) Categorizing a prognostic variable: review of methods, code for easy implementation and applications to decision-making about cancer treatments. Stat Med 19(1):113–132PubMedCrossRefGoogle Scholar
  6. 6.
    Sim SJ, Ro JY, Ordonez NG, Park YW, Kee KH, Ayala AG (1999) Metastatic renal cell carcinoma to the bladder: a clinicopathologic and immunohistochemical study. Mod Pathol 12(4):351–355PubMedGoogle Scholar
  7. 7.
    Shiraishi K, Mohri J, Inoue R, Kamiryo Y (2003) Metastatic renal cell carcinoma to the bladder 12 years after radical nephrectomy. Int J Urol 10(8):453–455. doi: 10.1046/j.1442-2042.2003.00652.x PubMedCrossRefGoogle Scholar
  8. 8.
    Kume H, Nyoumura S, Niimi A, Fujimura T, Fukuhara H, Ishikawa A, Nishimatsu H, Tomita K, Takeuchi T, Kitamura T (2007) Bladder recurrence of renal cell carcinoma: report of two cases. Nihon Hinyokika Gakkai Zasshi 98(5):718–722 (article in Japanese)PubMedGoogle Scholar
  9. 9.
    Nair HT, Little G (1991) Metastatic renal carcinoma: rare cause of outflow obstruction (a case report). J Postgrad Med 37(4):232–234Google Scholar
  10. 10.
    Abeshouse BS (1956) Metastasis to ureters and urinary bladder from renal carcinoma: report of two cases. J Int Coll Surg 25(1 Part 1):117–126Google Scholar
  11. 11.
    Shaw RE (1961) Metastasis to the bladder from carcinoma of the kidney. Brit J Surg 48:420–422. doi: 10.1002/bjs.18004821011 CrossRefGoogle Scholar
  12. 12.
    Bolkier M, Moskovitz B, Munichor M, Genesin Y, Levin DR (1993) Metastatic renal cell carcinoma to the bladder. Urol Int 50(2):101–103. doi: 10.1159/000282462 PubMedCrossRefGoogle Scholar
  13. 13.
    Kruck S, Scharpf M, Stenzl A, Bedke J (2013) A rare case of synchronous renal cell carcinoma of the bladder presenting with gross hematuria. Rare Tumors 5(2):72–74. doi: 10.4081/rt.2013.e19 PubMedCentralPubMedCrossRefGoogle Scholar
  14. 14.
    Doo SW, Kim WB, Kim BK, Yang WJ, Yoon JH, Jin SY, Song YS (2013) Metastasis of renal cell carcinoma to the bladder. Korean J Urol 54(1):69–72. doi: 10.4111/kju.2013.54.1.69 PubMedCentralPubMedCrossRefGoogle Scholar
  15. 15.
    Tanikawa K, Matsushita K (1990) Bladder metastasis from renal cell carcinoma three years after nephrectomy. Hinyokika Kiyo 36(8):927–929 (article in Japanese)PubMedGoogle Scholar
  16. 16.
    Hajdu SI, Savino A, Hajdu EO, Koss LG (1971) Cytologic diagnosis of renal cell carcinoma with the aid of fat stain. Acta Cytol 15(1):31–33PubMedGoogle Scholar
  17. 17.
    Butler MJ (1974) A solitary metastasis to the bladder from a renal adenocarcinoma. Br J Urol 46(5):584. doi: 10.1111/j.1464-410X.1974.tb03861.x PubMedCrossRefGoogle Scholar
  18. 18.
    Tashiro K, Kondo N, Ueda M, Ohishi Y, Wada T, Kido A, Masuda F, Machida T (1984) A case study with bladder metastasis of renal cell carcinoma and stomach cancer. Hinyokika Kiyo 30(2):249–252 (article in Japanese)PubMedGoogle Scholar
  19. 19.
    Harding IJ, Cranston D (1998) A long-term survivor with bladder metastasis from renal cell carcinoma. Int J Clin Pract 52(7):522PubMedGoogle Scholar
  20. 20.
    Vecchioli Scaldazza C, Morosetti C, Diamanti L, Magagnini M (1998) Metastases of the ureteral stump and bladder from renal cell carcinoma: report of a case. Minerva Urol Nefrol 50(3):191–194PubMedGoogle Scholar
  21. 21.
    Joshi DP, Shah RB, Montie JE, Lee CT (2002) Isolated recurrent renal cell carcinoma metastatic to the bladder. J Natl Med Assoc 94(10):912–914PubMedCentralPubMedGoogle Scholar
  22. 22.
    Antonelli A, Cozzoli A, Simeone C, Zani D, Zanotelli T, Portesi E, Cunico SC (2006) Surgical treatment of adrenal metastasis from renal cell carcinoma: a single-centre experience of 45 patients. BJU Int 97(3):505–508. doi: 10.1111/j.1464-410X.2006.05934.x PubMedCrossRefGoogle Scholar
  23. 23.
    Chung PH, Srinivasan R, Linehan WM, Pinto PA, Bratslavsky G (2012) Renal cell carcinoma with metastases to the gallbladder: four cases from the National Cancer Institute (NCI) and review of the literature. Urol Oncol 30(4):476–481. doi: 10.1016/j.urolonc.2010.04.010 PubMedCentralPubMedCrossRefGoogle Scholar
  24. 24.
    Antonelli A, Arrighi N, Corti S, Legramanti S, Zanotelli T, Cozzoli A, Cunico SC, Simeone C (2012) Surgical treatment of atypical metastasis from renal cell carcinoma (RCC). BJU Int 110(11 Pt B):E559–E563. doi:  10.1111/j.1464-410X.2012.11271.x
  25. 25.
    Tsui KH, Shvarts O, Smith RB, Figlin R, de Kernion JB, Belldegrun A (2000) Renal cell carcinoma: prognostic significance of incidentally detected tumors. J Urol 163(2):426–430PubMedCrossRefGoogle Scholar
  26. 26.
    Kuczyk MA, Anastasiadis AG, Zimmermann R, Merseburger AS, Corvin S, Stenzl A (2005) Current aspects of the surgical management of organ-confined, metastatic, and recurrent renal cell cancer. BJU Int 96(5):721–727. doi: 10.1111/j.1464-410X.2005.05771.x PubMedCrossRefGoogle Scholar
  27. 27.
    Kavolius JP, Mastorakos DP, Pavlovich C, Russo P, Burt ME, Brady MS (1998) Resection of metastatic renal cell carcinoma. J Clin Oncol 16(6):2261–2266PubMedGoogle Scholar
  28. 28.
    Swanson DA (2004) Surgery for metastases of renal cell carcinoma. Scand J Surg 93(2):150–155PubMedGoogle Scholar
  29. 29.
    Faure JP, Tuech JJ, Richer JP, Pessaux P, Arnaud JP, Carretier M (2001) Pancreatic metastasis of renal cell carcinoma: presentation, treatment and survival. J Urol 165(1):20–22. doi: 10.1097/00005392-200101000-00005 PubMedCrossRefGoogle Scholar
  30. 30.
    Raviv S, Eggener SE, Williams DH, Garnett JE, Pins MR, Smith ND (2002) Long-term survival after “drop metastases” of renal cell carcinoma to the bladder. Urology 60(4):697–699. doi: 10.1016/S0090-4295(02)01846-0 PubMedCrossRefGoogle Scholar
  31. 31.
    Matsuo M, Koga S, Nishikido M, Noguchi M, Sakaguchi M, Nomata K, Maruta N, Hayashi T, Kanetake H (2002) Renal cell carcinoma with solitary metachronous metastasis to the urinary bladder. Urology 60(5):911–912. doi: 10.1016/S0090-4295(02)01900-3 PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Kazuhiro Matsumoto
    • 1
    • 2
  • Nozomi Hayakawa
    • 1
    • 2
  • So Nakamura
    • 2
  • Mototsugu Oya
    • 1
  1. 1.Department of UrologyKeio University School of MedicineShinjuku-kuJapan
  2. 2.Department of UrologyTokyo Saiseikai Central HospitalMinato-kuJapan

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