Characterization of metal-texaphyrin complexes and preparation of radionuclide-texaphyrin complexes
This paper summarizes results achieved in labelling texaphyrin with radionuclides (e.g., with 177Lu) and characterization of the metal-texaphyrin complexes. Thin layer chromatography (TLC) method was used for the quality control of the 177Lu-labeled texaphyrin. Thermal analysis, mass spectroscopy (MS) and Fourier transform infrared spectroscopy (FT-IR) were used for the characterization of the Ca-texaphyrin, Lu-texaphyrin and Y-texaphyrin. The chemical and physical properties depend on the metal centrally placed into the cavity of the texaphyrin molecule. The labelling yield of the 177Lu-texaphyrin by the neutron irradiated Lu-Tex complex in the LVR-15 reactor was determined to be 40 %. The TLC technique is suitable for the separation of the 177Lu-Tex complex from the radionuclide 177Lu. The fact that texaphyrin exhibits a high affinity of bonding to cancer cells is of great advantage as no antibody has to be applied.