Czechoslovak Journal of Physics

, Volume 56, Issue 1, pp D719–D729 | Cite as

Characterization of metal-texaphyrin complexes and preparation of radionuclide-texaphyrin complexes

  • M. Reková
  • V. Král
  • V. Jedináková-Křížová
Nuclear Methods In Medicine, Radiopharmaceuticals, And Radiodiagnostics, Labelled Compounds


This paper summarizes results achieved in labelling texaphyrin with radionuclides (e.g., with 177Lu) and characterization of the metal-texaphyrin complexes. Thin layer chromatography (TLC) method was used for the quality control of the 177Lu-labeled texaphyrin. Thermal analysis, mass spectroscopy (MS) and Fourier transform infrared spectroscopy (FT-IR) were used for the characterization of the Ca-texaphyrin, Lu-texaphyrin and Y-texaphyrin. The chemical and physical properties depend on the metal centrally placed into the cavity of the texaphyrin molecule. The labelling yield of the 177Lu-texaphyrin by the neutron irradiated Lu-Tex complex in the LVR-15 reactor was determined to be 40 %. The TLC technique is suitable for the separation of the 177Lu-Tex complex from the radionuclide 177Lu. The fact that texaphyrin exhibits a high affinity of bonding to cancer cells is of great advantage as no antibody has to be applied.


Radionuclide Thin Layer Chromatography Lutetium Labelling Yield Mass Spectroscopy Spectrum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. [1]
    Sessler J. L. et al.: Acc. Chem. Res. 27 (1994) 43.CrossRefGoogle Scholar
  2. [2]
    Hannah S. et al.: J. Am. Chem. Soc. 124 (2002) 8416.CrossRefGoogle Scholar
  3. [3]
    Carde P. et al.: J. Clin. Onc. 19 (2001) 2074.Google Scholar
  4. [4]
    Sessler J. L. et al.: J. Am. Chem. Soc. 115 (1993) 10368.CrossRefGoogle Scholar
  5. [5]
    Sessler J. L. et al.: J. Alloys Compd. 249 (1997) 146.CrossRefGoogle Scholar
  6. [6]
    Young S. W. et al.: Photochem. Photobiol. 63 (1996) 829.Google Scholar
  7. [7]
    Sessler J. L. and Miller R. A.: Biochem. Pharmacol. 59 (2000) 733.CrossRefGoogle Scholar
  8. [8]
    Magda D. J. et al.: J Am. Chem. Soc. 117 (1995) 3629.CrossRefGoogle Scholar
  9. [9]
    Kubát P., Lang K., Zelinger Z., and Král V.: J. Inorg. Biochem. 99 (2005) 1670.CrossRefGoogle Scholar
  10. [10]
    Magda D., Miller R. A., Sessler, J. L., and Iverson B. L.: J. Am. Chem. Soc. 116 (1994) 7439.CrossRefGoogle Scholar
  11. [11]
    Kostenich G. et al.: J. Photochem. Photobiol. B 39 (1997) 36.CrossRefGoogle Scholar
  12. [12]
    Sessler J. L., Mody T. D., Hemmi G. W., and Lynch V.: Inorg. Chem. 32 (1993) 3175.CrossRefGoogle Scholar
  13. [13]
    Sessler J. L. et al.: Acc. Chem. Res. 27 (1994) 43.CrossRefGoogle Scholar

Copyright information

© Institute of Physics, Academy of Sciences of the Czech Republic 2006

Authors and Affiliations

  • M. Reková
    • 1
  • V. Král
    • 1
  • V. Jedináková-Křížová
    • 1
  1. 1.Department of Analytical ChemistryInstitute of Chemical TechnologyPrague 6Czech Republic

Personalised recommendations