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Cellular and Molecular Neurobiology

, Volume 37, Issue 4, pp 695–706 | Cite as

The Effects of Astilbin on Cognitive Impairments in a Transgenic Mouse Model of Alzheimer’s Disease

  • Dongmei Wang
  • Sanqiang Li
  • Jing Chen
  • Ling Liu
  • Xiaoying Zhu
Original Research

Abstract

Bioflavonoids are being utilised as neuroprotectants in the treatment of various neurological disorders, including Alzheimer’s disease (AD). Astilbin, a bioflavanoid, has been reported to have potent neuroprotective effects, but its preventive effects on amyloid-β (Aβ)-induced, Alzheimer’s disease-related, cognitive impairment, and the underlying mechanisms of these effects have not been well characterised. Five-month-old APPswe/PS1dE9 transgenic mice were randomly assigned to a vehicle group and two astilbin (either 20 or 40 mg/kg per day, intraperitoneally) groups. After 8 weeks of treatment, we observed beneficial effects of astilbin (40 mg/kg per day), including lessening learning and memory deficits and reducing plaque burden and Aβ levels. Furthermore, the expressions of both the cAMP responsive element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) were significantly increased and the disturbance of AKT/GSK-3β signalling pathway was markedly ameliorated in the hippocampus of astilbin-treated (40 mg/kg per day) group. Our data suggest that astilbin might be a potential therapeutic agent against AD.

Keywords

Astilbin APPswe/PS1dE9 mice Cognitive ability CREB/BDNF pathway 

Abbreviations

AD

Alzheimer’s disease

AST

Astilbin

BDNF

Brain-derived neurotrophic factor

CREB

CAMP responsive element-binding protein

DMSO

Dimethylsulfoxide

MAPK

The Ras-mitogen-activated protein kinase

MDA

Malondialdehyde

GSH

Glutathione

GSK-3β

Glycogen synthase kinase-3β

PI3K/AKT

Phosphatidylinositol 3 kinase/protein kinase B

PKA

The cAMP/protein kinase A

T-AOC

Total antioxidant capability

Notes

Acknowledgments

The present work was supported by National Natural Science Foundation of China (U1304806), the China Scholarship Council (No.201408410296), the Young Backbone Teachers Assistance Scheme of Henan Province Colleges and Universities, and the Scientific Research Fund of Henan University of Science and Technology (No.09001664).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Dongmei Wang
    • 1
  • Sanqiang Li
    • 2
  • Jing Chen
    • 3
  • Ling Liu
    • 1
  • Xiaoying Zhu
    • 1
  1. 1.Department of Pathogen Biology, Medical CollegeHenan University of Science and TechnologyLuoyangChina
  2. 2.Department of Biochemistry and Molecular Biology, Medical CollegeHenan University of Science and TechnologyLuoyangChina
  3. 3.Department of NeurologyThe Second Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

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