Cellular and Molecular Neurobiology

, Volume 37, Issue 2, pp 361–369 | Cite as

Long Noncoding RNA-Sox2OT Knockdown Alleviates Diabetes Mellitus-Induced Retinal Ganglion Cell (RGC) injury

  • Chao-Peng Li
  • Shu-Hong Wang
  • Wen-Qi Wang
  • Shu-Guang Song
  • Xiu-Ming Liu
Brief Communication


Retinal ganglion cell (RGC) injury is one of the important pathological features of diabetes-induced retinal neurodegeneration. Increasing attention has been paid to find strategies for protecting against RGC injury. Long noncoding RNAs (lncRNAs) have emerged as the key regulators of many cell functions. Here, we show that Sox2OT expression is significantly down-regulated in the retinas of STZ-induced diabetic mice and in the RGCs upon high glucose or oxidative stress. SOX2OT knockdown protects RGCs against high glucose-induced injury in vitro. Moreover, Sox2OT knockdown plays a neuroprotective role in diabetes-related retinal neurodegeneration in vivo. Sox2OT knockdown could regulate oxidative stress response in RGCs and diabetic mouse retinas. Sox2OT knockdown plays an anti-oxidative role via regulating NRF2/HO-1 signaling activity. Taken together, Sox2OT knockdown may be a therapeutic strategy for the prevention and treatment of diabetes-induced retinal neurodegeneration.


Diabetic retinopathy Retinal ganglion cell (RGC) Long noncoding RNA NRF2/HO-1 signaling 


Compliance with Ethical Standards

Conflict of interest

The authors report no conflict of interest.

Supplementary material

10571_2016_380_MOESM1_ESM.doc (39 kb)
Supplementary material 1 (DOC 39 kb)


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Chao-Peng Li
    • 1
  • Shu-Hong Wang
    • 1
  • Wen-Qi Wang
    • 1
  • Shu-Guang Song
    • 1
  • Xiu-Ming Liu
    • 1
  1. 1.Huai’ an First People’s HospitalNanjing Medical UniversityHuai anChina

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