The Postnatal Development of the Cerebellum— A fMRI and Silver Study
- 71 Downloads
The aim of this study was to evaluate the postnatal development of the cerebella of the pig and to compare this with the activation of the fMRI. The cells in the cerebella were studied by silver technique and the activation of the fMRI in the cerebella was initiated by flexion and extension of the hind paw. Our results showed an increase of the branching of the cells of the cerebellar cortex postnatally, coordinated with registration of fMRI active sites in the cerebella at 6-month postnatal. We concluded that the full maturation of the cerebella was around 6-month postnatal in the pig.
Key Wordscerebellum pig silver fMRI
Unable to display preview. Download preview PDF.
- Dickerson, J. W., Merat, A., and Widdowson, E. M. (1971). The effect of development on the gangliosides of pig brain. Biochem. J. 125:40P–41P.Google Scholar
- Dumont, I., Hou, X., Hardy, P., Peri, K. G., Beauchamp, M., Najarian, T., Molotchnikoff, S., Varma, D. R., and Chemtob, S. (1999). Developmental regulation of endothelial nitric oxide synthase in cerebral vessels of newborn pig by prostaglandin E(2). J. Pharmacol. Exp. Ther. 291:627–633.PubMedGoogle Scholar
- Erlander, M. G., Parliman, J. A., Draper, D. D., Christian, L. L., Murrin, L. C., Pfeiffer, R. F., and Beitz, D. C. (1985). Effects of L-dopa supplementation on concentrations of brain catechols, dopamine receptor binding, and the incidence of pale, soft, and exudative meat in stress-susceptible pigs. J. Anim. Sci. 61:914–923.PubMedGoogle Scholar
- Fang, M. R., Li, J. C., Gong, X. Y., Antonio, G. E., Lee, F., Kwong, W. H., Wai, S. M., and Yew, D. T. (2005). Myelination of the pig/s brain—a correlated MRI and histological study. Neurosignal. 14:102–108.Google Scholar
- Pond, W. G., Strachan, D. N., Sinha, Y. N., Walker, E. F. Jr., Dunn, J. A., and Barnes, R. H. (1969). Effect of protein deprivation of swine during all or part of gestation on birth weight, postnatal growth rate, and nucleic acid content of brain and muscle of progeny. J. Nutr. 99:61–67.PubMedGoogle Scholar
- Wawrzyniak, M., and Niespodziewanski, M. (1967). Acetylcholinesterase activity in the region of the internal grey matter of the pig cerebellum during ontogenesis. Folia Histochem. Cytochem. (Krakow) 5:389–398.Google Scholar