Cellulose

, Volume 25, Issue 1, pp 245–257 | Cite as

Amphiphilic xylan–cholic acid conjugates: synthesis and self-assembly behaviors in aqueous solution

  • Xinwen Peng
  • Zhihua Xiang
  • Fan Du
  • Jiewen Tan
  • Linxin Zhong
  • Runcang Sun
Original Paper
  • 72 Downloads

Abstract

A novel amphiphilic biopolymer was synthesized by incorporating hydrophobic segment cholic acid (CA) into hydrophilic segment carboxymethyl xylan (CX) through coupling agent. Structural characteristics and self-assembly behaviors of the amphiphilic conjugates in aqueous solution were investigated in detail. Results showed that the conjugates provided monodispersed self-assembled micelles in distilled water, with average diameters in the range of 90–135 nm, depending on the DS of CA. TEM and AFM images proved that the self-assembly micelles were spherical. The micelles were covered with negatively charged carboxymethyl xylan shells, exhibiting zeta potential about − 38 mV. The aggregation concentration of the conjugate (0.0079–1.25 × 10−2 g/L) was closely related to the DS of CA and solution pH. Moreover, CX–CA nanoparticles were sensitive to the pH of release media. The cellular uptake of DOX-loaded CX–CA nanoparticles was better than that of free DOX, and thus CX–CA nanoparticles can be used as a new carrier for antitumor drug delivery.

Keywords

Xylan Cholic acid Amphiphilic Micelle Self-assembly 

Notes

Acknowledgments

We wish to thank for the National Natural Science Foundation of China (31430092, 21404043, 21336002), Guangdong Natural Science Funds for Distinguished Young Scholar (2015A010105005), Tip-top Scientific and Technical Innovative Youth Talents of Guangdong special support program (2015TQ01C488), Science and Technology Program of Guangdong (2015A010105005), State Key Laboratory of Pulp and Paper Engineering (2017TS03) and Fundamental Research Funds for the Central Universities.

Supplementary material

10570_2017_1595_MOESM1_ESM.doc (1.1 mb)
Supplementary material 1 (DOC 1079 kb)

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2017

Authors and Affiliations

  • Xinwen Peng
    • 1
  • Zhihua Xiang
    • 1
  • Fan Du
    • 1
  • Jiewen Tan
    • 1
  • Linxin Zhong
    • 1
  • Runcang Sun
    • 2
  1. 1.State Key Laboratory of Pulp and Paper EngineeringSouth China University of TechnologyGuangzhouChina
  2. 2.Beijing Key Laboratory of Lignocellulosic ChemistryBeijing Forestry UniversityBeijingChina

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