Abstract
An injectable polysaccharide hydrogel based on cellulose acetoacetate (CAA), hydroxypropyl chitosan (HPCS), and amino-modified cellulose nanocrystals (CNC-NH2) was prepared under physiological conditions. CNC-NH2 acted as both physical and chemical cross-linker. The effects of CNC-NH2 loading on the mechanical properties, internal morphology and gelation time were investigated; the maximum storage modulus was observed for a gel containing 0.80 wt% of CNC-NH2. The structure and properties of the polysaccharide hydrogel were characterized by Fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, scanning electron microscopy, Raman spectroscopy and rheology testing. The polysaccharide hydrogel exhibited pH- responsive properties and excellent stability under physiological conditions. The hydrogel also exhibited self-healing behavior under acidic conditions via enamine bond exchange. In addition, CCK-8 cytotoxicity study with fibroblast L929 cells demonstrates good biocompatibility of CNCs reinforced hydrogels.
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Acknowledgments
This work was financially supported by the National Natural Science Foundation of China (No. 51403035), the Natural Science Foundation of Inner Mongolia (2015MS0209), and the Fundamental Research Funds for the Central Universities (No. 15D110510).
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Liu, H., Li, C., Wang, B. et al. Self-healing and injectable polysaccharide hydrogels with tunable mechanical properties. Cellulose 25, 559–571 (2018). https://doi.org/10.1007/s10570-017-1546-9
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DOI: https://doi.org/10.1007/s10570-017-1546-9