, Volume 25, Issue 1, pp 537–547 | Cite as

Modification of cellulose thin films with lysine moieties: a promising approach to achieve antifouling performance

  • Thomas Elschner
  • Matej Bračič
  • Tamilselvan Mohan
  • Rupert Kargl
  • Karin Stana Kleinschek
Original Paper


Thin films of trimethylsilyl cellulose are obtained by spin coating and regenerated to cellulose. The surface is activated with N,N′-carbonyldiimidazole and aminolysis with lysine is carried out in aqueous solution to yield a cellulose lysine carbamate film. The surface is analytically characterized by ATR-IR spectroscopy, zetapotential measurements, contact angle measurements, and atomic force microscopy. The amount of functional groups is determined by pH potentiometric titration as well as the ninhydrin test and is in the range of 25 pmolcm−2. Adsorption of bovine serum albumine (BSA) and fibrinogen on the cellulose film and the cellulose lysine carbamate surface is studied at different pH values by quartz crystal microbalance with dissipation monitoring (QCM-D). The adsorption of BSA is significantly reduced by modification with lysine. At physiological pH value (7.4) the adsorption of fibrinogen is even six times lower (1.0 mgm−2) compared to the pure cellulose surface. Thus, cellulose thin films with lysine moieties are promising candidates for hemo-compatible antifouling surfaces in the field of blood contacting devices.


Thin films Cellulose lysine carbamate Protein adsorption Fibrinogen BSA 



The financial support of the German Research Foundation (DFG, Research Fellowship [Grant Number EL843/1-1]) is gratefully acknowledged. The authors thank Ana Bratuša and Tanja Kos for their experimental assistance.


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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Thomas Elschner
    • 1
  • Matej Bračič
    • 1
  • Tamilselvan Mohan
    • 1
    • 2
  • Rupert Kargl
    • 1
  • Karin Stana Kleinschek
    • 1
  1. 1.Laboratory for Characterization and Processing of Polymers, Faculty of Mechanical EngineeringUniversity of MariborMariborSlovenia
  2. 2.Institute of ChemistryUniversity of GrazGrazAustria

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