, Volume 24, Issue 1, pp 219–229 | Cite as

Use of electrospinning to directly fabricate three-dimensional nanofiber stacks of cellulose acetate under high relative humidity condition

  • Miao Cheng
  • Zongyi Qin
  • Shuo Hu
  • Houyong Yu
  • Meifang Zhu
Original Paper


Unique structure-controllable three-dimensional (3D) nanofiber stacks of cellulose acetate (CA) were fabricated successfully by simply increasing relative humidity (RH) during the electrospinning process. It is found that once the RH exceeding 60 %, 3D flocculent nanofiber stacks would grow on the flat plate collector toward the needle tip without using special assisting apparatus or preparing special electrospinning solution. Compared with those obtained at low RH, the as-prepared nanofibers fabricated under high RH condition exhibited similar nanofiber diameter, density and porosity, and more importantly, 3D flocculent structures instead of typical two-dimensional (2D) electrospun non-woven mats, which would contribute to a significant improvement on the hydrophilicity. It is believed that rapid solidification of CA during the jet process and strong charge repulsion among CA nanofibers play important roles in the formation of 3D nanofibrous structure. Furthermore, these 3D flocculent nanofiber scaffolds exhibited better cytocompatibilities with human MG-63 cells than common 2D nanofibrous mats. Thus a facile and effective approach was presented to prepare 3D nanofiber stacks with tunable and reproducible properties for biodegradable scaffold applications.


Cellulose acetate Electrospun nanofibers 3D nanofiber stacks Relative humidity 



This work has been financially supported by Program for Changjiang Scholars and Innovative Research Team in University (IRT1221) and Key Basic Research Project of Science and Technology of Shanghai (15Q10622). Dr. Miao Cheng kindly acknowledges the support from the Innovation Research Funds for the Doctoral candidate of Donghua University (15D310606). Dr. Hou-Yong Yu would like to thank the support from the State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University (LK1428).


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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  1. 1.State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Material Science and EngineeringDonghua UniversityShanghaiChina
  2. 2.The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and TextileZhejiang Sci-Tech UniversityHangzhouChina

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