Novel pH-responsive graft copolymer based on HPMC and poly(acrylamide) synthesised by microwave irradiation: application in controlled release of ornidazole
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Herein, the microwave-assisted grafting method was employed for the development of a novel pH-responsive graft copolymer derived from polyacrylamide-modified hydroxypropyl methyl cellulose [g-HPMC (M)]. The synthesised copolymer has been used for in vitro sustained release of ornidazole. Various characterizations confirm the formation of graft copolymer. Swelling studies indicate the pH-dependent swelling behaviour, while deswelling studies suggest that g-HPMC (M) shows faster deswelling in response to change in pH and/temperature. The cell viability study signifies that g-HPMC (M) is cytocompatible. The in-vitro release study demonstrates that g-HPMC (M) delivers ornidazole specifically in the colon pH, without release of the drug in the acidic environment, ensuring g-HPMC (M) as an ideal candidate for orally administered colonic drug carriers. The kinetics and mechanism of drug release suggest that it follows a non-Fickian release mechanism.
KeywordsBiodegradable Drug delivery Graft copolymer Microwave Ornidazole
Authors earnestly acknowledge the financial support from the Department of Science and Technology, New Delhi, India, in the form of a research grant (no. SR/FT/CS-094/2009) to carry out the reported investigation.
- Pal S, Nasim T, Patra A, Ghosh S, Panda AB (2010) Microwave assisted synthesis of polyacrylamide grafted dextrin (Dxt-g-PAM): development and application of a novel polymeric flocculant. Int J Biol Macromol 47:623–631Google Scholar
- Peppas NA (1985) Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv 60:110–111Google Scholar
- Rutgreets P, Assche GV, Vermeire S, D’Haens G, Baert F, Noman M, Aerden I, Hertogh G, Geboes K, Hiele M, D’Hoore A, Penninckx F (2005) Ornidazole for prophylaxis of postoperative Crohn’s disease recurrence: a randomized, double-blind placebo-controlled trial. Gastroenterology 128:856–861CrossRefGoogle Scholar
- Singh RP, Pandey JK, Rutot D, Degree Ph, Dubois Ph (2003) Biodegradation of poly(ε-caprolactone)/starch blends and composites in composting and culture environments: the effect of compatibilization on the inherent biodegradability of the host polymer. Carbohydr Res 338:1759–1769CrossRefGoogle Scholar