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Cellulose

, Volume 22, Issue 1, pp 313–327 | Cite as

Novel pH-responsive graft copolymer based on HPMC and poly(acrylamide) synthesised by microwave irradiation: application in controlled release of ornidazole

  • Raghunath Das
  • Dipankar Das
  • Paulomi Ghosh
  • Animesh Ghosh
  • Santanu Dhara
  • A. B. Panda
  • Sagar Pal
Original Paper

Abstract

Herein, the microwave-assisted grafting method was employed for the development of a novel pH-responsive graft copolymer derived from polyacrylamide-modified hydroxypropyl methyl cellulose [g-HPMC (M)]. The synthesised copolymer has been used for in vitro sustained release of ornidazole. Various characterizations confirm the formation of graft copolymer. Swelling studies indicate the pH-dependent swelling behaviour, while deswelling studies suggest that g-HPMC (M) shows faster deswelling in response to change in pH and/temperature. The cell viability study signifies that g-HPMC (M) is cytocompatible. The in-vitro release study demonstrates that g-HPMC (M) delivers ornidazole specifically in the colon pH, without release of the drug in the acidic environment, ensuring g-HPMC (M) as an ideal candidate for orally administered colonic drug carriers. The kinetics and mechanism of drug release suggest that it follows a non-Fickian release mechanism.

Keywords

Biodegradable Drug delivery Graft copolymer Microwave Ornidazole 

Notes

Acknowledgments

Authors earnestly acknowledge the financial support from the Department of Science and Technology, New Delhi, India, in the form of a research grant (no. SR/FT/CS-094/2009) to carry out the reported investigation.

Supplementary material

10570_2014_511_MOESM1_ESM.docx (2.2 mb)
Supplementary material 1 (DOCX 2241 kb)

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Raghunath Das
    • 1
  • Dipankar Das
    • 1
  • Paulomi Ghosh
    • 2
  • Animesh Ghosh
    • 3
  • Santanu Dhara
    • 2
  • A. B. Panda
    • 4
  • Sagar Pal
    • 1
  1. 1.Polymer Chemistry Laboratory, Department of Applied ChemistryIndian School of MinesDhanbadIndia
  2. 2.School of Medical Science and TechnologyIndian Institute of TechnologyKharagpurIndia
  3. 3.Department of Pharmaceutical SciencesBirla Institute of TechnologyMesraIndia
  4. 4.Disciplines of Inorganic Materials and CatalysisCentral Salt and Marine Chemicals Research Institute (CSIR-CSMCRI)BhavnagarIndia

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