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Cellulose

, Volume 21, Issue 3, pp 1921–1932 | Cite as

Antibacterial modification of cellulose fibers by grafting β-cyclodextrin and inclusion with ciprofloxacin

  • Chao Dong
  • Ying Ye
  • Liying Qian
  • Guanglei Zhao
  • Beihai He
  • Huining Xiao
Original Paper

Abstract

Antibacterial-modified cellulose fiber was prepared by covalently bonding β-cyclodextrin (β-CD) with cellulose fiber via citric acid (CA) as crosslinking agent, followed by the inclusion of ciprofloxacin hydrochloride (CipHCl) as antibiotic. Effects of reaction time, temperature, concentration of β-cyclodextrin citrate (CA-β-CD) and pH on the grafting reaction were investigated, and the grafting ratio of β-CD onto cellulose fibers was 9.7 % at optimal conditions; the loading and releasing behaviors of CipHCl into/from β-CD grafted cellulose fibers were also revealed, the load amount of CipHCl into grafted cellulose fibers increased remarkably, and the release of CipHCl from the grafted cellulose fibers was prolonged. The microstructure, phase and thermal stability of modified cellulose fibers were characterized by FT-IR, 13C CPMAS NMR, X-ray diffraction and TGA. Considerably longer bacterial activity against E. coli and S. aureus was observed for grafted fibers loading CipHCl compared to virgin ones. Optical and mechanical properties of the paper sheets decreased generally with more antibacterial-modified fibers added.

Keywords

Cellulose fiber β-Cyclodextrin Grafting Antibacterial activity 

Notes

Acknowledgments

This work was supported by the grants from the National Natural Science Foundation of China (grant nos. 31200457 and 31270636), NSERC Sentinel Bioactive Paper Network (Canada) and the Fundamental Research Funds for the Central Universities (2013ZZ0072).

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.State Key Laboratory of Pulp and Paper EngineeringSouth China University of TechnologyGuangzhouPeople’s Republic of China
  2. 2.Department of Chemical EngineeringUniversity of New BrunswickFrederictonCanada

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