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Synthesis and characterization of a novel polymeric hydrogel based on hydroxypropyl methyl cellulose grafted with polyacrylamide

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Abstract

A novel hydrogel has synthesized by grafting polyacrylamide chains onto hydroxypropyl methylcellulose in presence of potassium persulphate as initiator using solution polymerization technique. The reaction was carried out in homogeneous aqueous medium. The effect of reaction parameters on percentage of grafting (% G) and grafting efficiency (% GE) were discussed. The parameters were varied systematically to achieve the best hydrogel. Developed hydrogels were characterized by various materials characterization techniques. The dynamic and equilibrium swelling properties of hydrogels were investigated as a function of pH and time in various buffer solutions similar to that of gastric and intestinal fluid. Results showed that with increase in % G and % GE, the rate of swelling decreases, which can opens the door for further study of their utilization as matrices for controlled/sustained/targeted drug delivery.

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Acknowledgments

The corresponding author (SP) earnestly acknowledges the financial support from Department of Science and Technology, New Delhi, India in form of a research grant (NO: SR/FT/CS-094/2009) to carry out the reported investigation.

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Authors and Affiliations

  1. Polymer Chemistry Laboratory, Department of Applied Chemistry, Indian School of Mines, Dhanbad, 826004, India

    R. Das & Sagar Pal

  2. Disciplines of Inorganic Materials and Catalysis, CSMCRI, Bhavnagar, 364021, India

    A. B. Panda

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  1. R. Das
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  2. A. B. Panda
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  3. Sagar Pal
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Correspondence to A. B. Panda or Sagar Pal.

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Das, R., Panda, A.B. & Pal, S. Synthesis and characterization of a novel polymeric hydrogel based on hydroxypropyl methyl cellulose grafted with polyacrylamide. Cellulose 19, 933–945 (2012). https://doi.org/10.1007/s10570-012-9692-6

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  • DOI: https://doi.org/10.1007/s10570-012-9692-6

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