Cell Biology and Toxicology

, Volume 28, Issue 6, pp 435–442 | Cite as

Benign prostate hyperplasia and stem cells: a new therapeutic opportunity



Most men over 50 experience some lower urinary tract symptoms of nocturia, poor stream, urgency and frequency for urination, due to hyperplastic enlargement of the prostate (benign prostate hyperplasia, BPH). BPH is thought to be a disease with multiple aetiologies including hormone signalling, disruption of proliferation and apoptosis dynamics and chronic inflammation with changes in the morphology and phenotype of the prostate stroma. It has been proposed, recently, that stromal stem cells in prostate may be caused by the development of BPH. This review focuses on this putative role of stromal stem or stem-like cells in the development of BPH and assesses the potential of targeting the stem cells for the treatment of BPH.


Benign prostate hyperplasia Drug targeting Stem cells Stroma 



Lower urinary tract symptoms


Benign prostate hyperplasia


Central zone




Mesenchymal stem cell


Peripheral zone


Stem cell


Stem cell antigen


Stromal stem cell


Transitional zone


Terminal deoxynucleotidyl transferase dUTP Nick end labelling



We would like to thank Prostate Action UK (AA and MN) and the Prostate Cancer Research Centre (AA) for their financial support.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Prostate Cancer Research Centre, Research Department of Urology, Charles Bell HouseUniversity College LondonLondonUK

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