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[Zn(l-proline)2] Catalyzed One-Pot Synthesis of Propargylamines Under Solvent-Free Conditions

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Abstract

A simple, one-pot, three-component, green synthesis of a wide range of propargylamines is reported by A3-coupling (aldehyde, alkyne and amine) via C–H activation of alkynes using [Zn(l-proline)2] as an efficient and reusable heterogeneous catalyst. High catalytic activity was achieved in comparatively low temperature under solvent-free conditions. All reactions were carried out in an open atmosphere without the use of any co-catalyst/additive.

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Acknowledgements

We are thankful to the CRF IIT (ISM), Dhanbad and SAIF Panjab University, Chandigarh for providing help in the analysis of the samples. Samaresh Layek, Bhumika Agrahari and Anuradha acknowledges the receipt of IIT (ISM) fellowship. Shweta Kumari also acknowledges the receipt of Dr. D.S. Kothari Post-Doctoral Fellowship.

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Authors and Affiliations

  1. Department of Applied Chemistry, Indian Institute of Technology (ISM), Dhanbad, 826004, India

    Samaresh Layek, Bhumika Agrahari, Shweta Kumari,  Anuradha & Devendra D. Pathak

Authors
  1. Samaresh Layek
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  2. Bhumika Agrahari
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  3. Shweta Kumari
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  4. Anuradha
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  5. Devendra D. Pathak
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Corresponding author

Correspondence to Devendra D. Pathak.

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Layek, S., Agrahari, B., Kumari, S. et al. [Zn(l-proline)2] Catalyzed One-Pot Synthesis of Propargylamines Under Solvent-Free Conditions. Catal Lett 148, 2675–2682 (2018). https://doi.org/10.1007/s10562-018-2449-6

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  • DOI: https://doi.org/10.1007/s10562-018-2449-6

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