[Zn(l-proline)2] Catalyzed One-Pot Synthesis of Propargylamines Under Solvent-Free Conditions

  • Samaresh Layek
  • Bhumika Agrahari
  • Shweta Kumari
  • Anuradha
  • Devendra D. Pathak


A simple, one-pot, three-component, green synthesis of a wide range of propargylamines is reported by A3-coupling (aldehyde, alkyne and amine) via C–H activation of alkynes using [Zn(l-proline)2] as an efficient and reusable heterogeneous catalyst. High catalytic activity was achieved in comparatively low temperature under solvent-free conditions. All reactions were carried out in an open atmosphere without the use of any co-catalyst/additive.

Graphical Abstract


C–C and C–N coupling reaction C–H activation Propargylamines [Zn(l-proline)2



We are thankful to the CRF IIT (ISM), Dhanbad and SAIF Panjab University, Chandigarh for providing help in the analysis of the samples. Samaresh Layek, Bhumika Agrahari and Anuradha acknowledges the receipt of IIT (ISM) fellowship. Shweta Kumari also acknowledges the receipt of Dr. D.S. Kothari Post-Doctoral Fellowship.

Supplementary material

10562_2018_2449_MOESM1_ESM.pdf (2.3 mb)
Supplementary material 1 (PDF 2338 KB)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Samaresh Layek
    • 1
  • Bhumika Agrahari
    • 1
  • Shweta Kumari
    • 1
  • Anuradha
    • 1
  • Devendra D. Pathak
    • 1
  1. 1.Department of Applied ChemistryIndian Institute of Technology (ISM)DhanbadIndia

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