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Catalysis Letters

, Volume 148, Issue 6, pp 1610–1621 | Cite as

Chiral Autocatalysis and Mirror Symmetry Breaking

  • Andrew J. Gellman
  • Karl-Heinz Ernst
Perspective

Abstract

Highly enantioselective production of chiral compounds by chiral catalysis is one of the most challenging forms of catalytic selectivity. In this perspective, we argue by examples that the key to achieving high enantioselectivity lies in processes with non-linear kinetics or equilibria that effectively amplify small differences in enantiospecific energetics. Examples of such processes have been uncovered over the past decade and include autocatalysis, surface explosion reactions, stirring or grinding of crystallites, and cooperative self-assembly.

Graphical Abstract

Keywords

Chirality Enantioselectivity Autocatalysis Surface explosion Sergeants-and-soldiers Mirror symmetry breaking Chiral amplification 

Notes

Acknowledgements

AJG acknowledges support from the US Dept. of Energy under Grant No. DE-SC0008703. Support by the Schweizerischer Nationalfonds zur Förderung der Wissenschaften (grants # 200020_163296, 200021_152559, CRSII5_173720) is gratefully acknowledged. KHE thanks Jack Dunitz, Bart Kahr and Meir Lahav for fruitful discussions.

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Authors and Affiliations

  1. 1.Department of Chemical EngineeringCarnegie Mellon UniversityPittsburghUSA
  2. 2.EmpaSwiss Federal Laboratories for Materials Science and TechnologyDübendorfSwitzerland
  3. 3.Department of ChemistryUniversity of ZurichZurichSwitzerland

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