Catalysis Letters

, Volume 141, Issue 8, pp 1142–1148 | Cite as

An Efficient Process for the Cyclization of N-β-hydroxyethyl-N-methyl-1,3-propanediamine to N-methylhomopiperazine Over Cu20Cr10Mg10/γ-Al2O3

  • Fan Yang
  • Zhiwei Wu
  • Jianchao Ma
  • Huabang Wang
  • Yang Li
  • Ligong Chen


Continuous synthesis of N-methylhomopiperazine over Cu–Cr–Mg/γ-Al2O3 has been developed. The doped Cr improves the dispersion of the Cu0 particles and inhibits the generation of CuAl2O4 so that the Cu0 particles are retained as the active sites. Doped Mg neutralizes the strong acid sites in Cu20Cr10Mg10/γ-Al2O3, and led to a decrease in coking side reactions. The reaction parameters were optimized and N-methylhomopiperazine was obtained in a yield of 66%.

Graphical Abstract

A continuous process for the preparation of N-methylhomopiperazine and homopiperazine has been developed. The cyclization of N-β-hydroxyethyl-N-methyl-1,3-propanediamine and N-β-hydroxyethyl-N-1,3-propanediamine proceeded effectively over a Cu20Cr10Mg10/γ-Al2O3 catalyst in a fixed-bed reactor.


Methylhomopiperazine Homopiperazine Cyclization CuCrMg/γ-Al2O3 catalyst 



Financial support was provided by the National Natural Science Foundation of China (Grant No. 20376057).


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Fan Yang
    • 1
  • Zhiwei Wu
    • 1
  • Jianchao Ma
    • 1
  • Huabang Wang
    • 1
  • Yang Li
    • 1
  • Ligong Chen
    • 1
  1. 1.School of Chemical Engineering and Technology, Tianjin UniversityTianjinPeople’s Republic of China

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