An Efficient Process for the Cyclization of N-β-hydroxyethyl-N-methyl-1,3-propanediamine to N-methylhomopiperazine Over Cu20Cr10Mg10/γ-Al2O3
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Continuous synthesis of N-methylhomopiperazine over Cu–Cr–Mg/γ-Al2O3 has been developed. The doped Cr improves the dispersion of the Cu0 particles and inhibits the generation of CuAl2O4 so that the Cu0 particles are retained as the active sites. Doped Mg neutralizes the strong acid sites in Cu20Cr10Mg10/γ-Al2O3, and led to a decrease in coking side reactions. The reaction parameters were optimized and N-methylhomopiperazine was obtained in a yield of 66%.
KeywordsMethylhomopiperazine Homopiperazine Cyclization CuCrMg/γ-Al2O3 catalyst
Financial support was provided by the National Natural Science Foundation of China (Grant No. 20376057).
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