Catalysis Letters

, Volume 131, Issue 3–4, pp 432–439 | Cite as

Highly Enantioselective Organocatalytic Addition of Ethyl Trifluoropyruvate to Ketones with Subzero Temperature Microwave Activation

  • Shainaz M. Landge
  • Béla Török


An enantioselective organocatalytic microwave-assisted method for the addition of ethyl trifluoropyruvate to ketones to synthesize highly enantiomerically enriched organofluorine synthons is described. Besides the high yields, diastereo- and enantioselectivities, the most important observation is that the use of microwave irradiation at subzero temperatures proved to be beneficial. The results indicate that subzero temperature microwave chemistry is a potentially intriguing tool for asymmetric synthesis.


Microwave irradiation Asymmetric synthesis Organofluorine Subzero temperature Organocatalysis 



Financial support provided by the University of Massachusetts Boston, and National Institute of Health (R-15 AG025777-02) is gratefully acknowledged.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of Massachusetts BostonBostonUSA

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