Catalysis Letters

, Volume 118, Issue 3–4, pp 219–223 | Cite as

An Environmentally Friendly Route for the Synthesis of Benzofurane Derivatives using Selective Ring Acylation of Resorcinol

  • Sándor Békássy
  • Béla Ágai
  • János Farkas
  • Eszter Gábor
  • Mária Ferenczi
  • François Figueras


The synthesis of 2,2-dimethyl-2,3-dihydro-benzofuran-6-ol, an important intermediate for benzofurane derivatives having pharmaceutical activity, is achieved by an environmentally friendly pathway. Whereas the current synthesis method, based on resorcinol dimethylether, uses or produces harmful, corrosive and dangerous reagents/materials, the procedure proposed here achieves 60% preparative yield for the selective direct ring acylation of resorcinol with isobutyryl chloride, using a solvent-free reaction catalysed by solid acids.


Clays Acylation Resorcinol Solvent-free reaction Benzofurane precursor 



The financial support of the Hungarian Scientific Research Fund (OTKA T-037757) is gratefully acknowledged. This publication was prepared within the framework of the Hungarian-French intergovernmental scientific and technological cooperation, TéT project No. F-8/02.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Sándor Békássy
    • 1
  • Béla Ágai
    • 1
  • János Farkas
    • 1
  • Eszter Gábor
    • 1
  • Mária Ferenczi
    • 1
  • François Figueras
    • 2
  1. 1.Department of Organic Chemical TechnologyBudapest University of Technology and EconomicsBudapestHungary
  2. 2.Institut de Recherches sur la CatalyseVilleurbanneFrance

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