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An Environmentally Friendly Route for the Synthesis of Benzofurane Derivatives using Selective Ring Acylation of Resorcinol

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Abstract

The synthesis of 2,2-dimethyl-2,3-dihydro-benzofuran-6-ol, an important intermediate for benzofurane derivatives having pharmaceutical activity, is achieved by an environmentally friendly pathway. Whereas the current synthesis method, based on resorcinol dimethylether, uses or produces harmful, corrosive and dangerous reagents/materials, the procedure proposed here achieves 60% preparative yield for the selective direct ring acylation of resorcinol with isobutyryl chloride, using a solvent-free reaction catalysed by solid acids.

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Acknowledgments

The financial support of the Hungarian Scientific Research Fund (OTKA T-037757) is gratefully acknowledged. This publication was prepared within the framework of the Hungarian-French intergovernmental scientific and technological cooperation, TéT project No. F-8/02.

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Authors and Affiliations

  1. Department of Organic Chemical Technology, Budapest University of Technology and Economics, Budapest, 1521, Hungary

    Sándor Békássy, Béla Ágai, János Farkas, Eszter Gábor & Mária Ferenczi

  2. Institut de Recherches sur la Catalyse, 2 Av. Albert Einstein, Villeurbanne, 69626, France

    François Figueras

Authors
  1. Sándor Békássy
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  2. Béla Ágai
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  3. János Farkas
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  4. Eszter Gábor
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  5. Mária Ferenczi
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  6. François Figueras
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Correspondence to Sándor Békássy.

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Békássy, S., Ágai, B., Farkas, J. et al. An Environmentally Friendly Route for the Synthesis of Benzofurane Derivatives using Selective Ring Acylation of Resorcinol. Catal Lett 118, 219–223 (2007). https://doi.org/10.1007/s10562-007-9173-y

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  • DOI: https://doi.org/10.1007/s10562-007-9173-y

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