Catalysis Letters

, Volume 105, Issue 1–2, pp 41–45 | Cite as

Role of Acetic Acid Added to the Reaction Media for the Enantio-differentiating Hydrogenation of Methyl Acetoacetate Over a Tartaric Acid-modified Nickel Catalyst

  • Tsutomu Osawa
  • Masashi Ando
  • Saori Sakai
  • Tadao Harada
  • Osamu Takayasu

The role of acetic acid added to the reaction media for the enantio-differentiating hydrogenation of methyl acetoacetate over a (R,R)-tartaric acid-in-situ-modified nickel catalyst was studied from the viewpoint of the hydrogenation rate during repeated runs. The hydrogenation of methyl acetoacetate on the “enantio-differentiating sites” of a tartaric acid-modified nickel catalyst was specifically accelerated by the acetic acid added to the reaction media to increase the enantio-differentiating ability of the catalyst. In order to increase the enantio-differentiating ability, the addition of acetic acid to the reaction media was required in each run during the repeated use of the catalyst.


tartaric acid-modified nickel enantio-differentiating hydrogenation rate acetic acid site specific acceleration repeated uses 


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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Tsutomu Osawa
    • 1
  • Masashi Ando
    • 1
  • Saori Sakai
    • 1
  • Tadao Harada
    • 2
  • Osamu Takayasu
    • 1
  1. 1.Faculty of ScienceToyama UniversityToyamaJapan
  2. 2.Faculty of Science and TechnologyRyukoku UniversityOtsuJapan

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