Tumor biobank plays a pivotal role in cancer biomedical research. The collection of a high variety of biological samples, including DNA, RNA, tissues, cells, blood, plasma and other body fluids, represents a necessary step to plan new strategies in the improvement of oncological patient care. Since 1985, a consolidated experience in biobanking management has been developed at the University of Siena (Italy). During these years, some information about clinico-pathology, surgery and a high number of human bispecimens have been collected. Herein, we described our experience in sampling management to improve the cancer research and the patient care.
Tumor biobank Biospecimen collection Surgery
This is a preview of subscription content, log in to check access.
We thank all the patients who donated tissue samples for biobanking assessment. This work was supported by the ‘Gene expression profile and therapeutic implication in gastric cancer. From the clinical overview to the translational research’ Grant ITT-2007 from the Istituto Toscano Tumori and by EU FP7 Marie Curie GastroGlycoExplorer Initial Training Network Grant 2013.
Conflict of interest
The authors indicated no potential conflicts of interest.
Corso G, Pedrazzani C, Marrelli D et al (2010) Familial gastric cancer and Li-Fraumeni syndrome. Eur J Cancer Care 19:377–381CrossRefGoogle Scholar
Corso Velho S, Paredes J et al (2011) Oncogenic mutations in gastric cancer with microsatellite instability. Eur J Cancer 47:443–451CrossRefPubMedGoogle Scholar
Corso G, Pascale V, Marrelli D et al (2012) Ultraviolet radiation resistance-associated polyadenine deletions in human gastric cancer. Hum Pathol 43:961–962CrossRefPubMedGoogle Scholar
Corso G, Pascale V, Flauti G et al (2013a) Oncogenic mutations and microsatellite instability phenotype predict specific anatomical subsite in colorectal cancer patients. Eur J Hum Genet 21:1383–1388CrossRefPubMedCentralPubMedGoogle Scholar
Corso G, Carvalho J, Marrelli D et al (2013b) Somatic mutations and deletions of the E-cadherin gene predict poor survival of patients with gastric cancer. J Clin Oncol 31:868–875CrossRefPubMedGoogle Scholar
Isabelle M, Teodorovic I, Morente MM et al (2006) TuBaFrost 5: multifunctional central database application for a European tumor bank. Eur J Cancer 42:3103–3109CrossRefPubMedGoogle Scholar
Japanese Gastric Cancer Association (2011) Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer 14:101–112CrossRefGoogle Scholar
Marrelli Morgagni P, de Manzoni G et al (2012) Prognostic value of the 7th AJCC/UICC TNM classification of noncardia gastric cancer: analysis of a large series from specialized Western centers. Ann Surg 255:486–491CrossRefPubMedGoogle Scholar
Morente MM, Mager R, Alonso S et al (2006) TuBaFrost 2: standardising tissue collection and quality control procedures for a European virtual frozen tissue bank network. Eur J Cancer 42:2684–2691CrossRefPubMedGoogle Scholar
Rodrigues M, Vitó I, Santos R et al (2009) Establishment of a Tumour Bank: the experience of the Department of Pathology of Hospital S. João (Porto, Portugal). Cell Tissue Bank 10:75–77CrossRefPubMedGoogle Scholar
Roviello F, Marrelli D, Morgagni P et al (2002) Survival benefit of extended D2 lymphadenectomy in gastric cancer with involvement of second level lymph nodes: a longitudinal multicenter study. Ann Surg Oncol 9:894–900CrossRefPubMedGoogle Scholar
Vaught J, Rogers J, Carolin T et al (2011) Biobankonomics: developing a sustainable business model approach for the formation of a human tissue biobank. J Natl Cancer Inst Monogr 2011:24–31CrossRefPubMedGoogle Scholar
Verlato G, Roviello F, Marchet A et al (2009) Indexes of surgical quality in gastric cancer surgery: experience of an Italian network. Ann Surg Oncol 16:594–602CrossRefPubMedGoogle Scholar