Cell and Tissue Banking

, Volume 13, Issue 4, pp 577–586 | Cite as

Fresh-frozen human bone allograft in vertical ridge augmentation: clinical and tomographic evaluation of bone formation and resorption

  • Luis Guilherme Scavone Macedo
  • Luiz Antonio Mazzucchelli-Cosmo
  • Nelson Luiz MacedoEmail author
  • Adriana Socorro Ferreira Monteiro
  • Wilson Roberto Sendyk


The aim of the current study is to evaluate fresh-frozen human bone allografts (FHBAs) used in vertical ridge augmentation clinically and by computed tomography, and to analyze the resulting bone formation and graft resorption. Sixteen FHBAs were grafted in the maxillae and mandibles of 9 patients. The FHBAs, which were provided by the Musculoskeletal Tissue Bank of Marilia Hospital (Unioss), were frozen at −80°C. After 7 months, dental implants were placed and bone parameters were evaluated. Vertical bone formation was measured by computerized tomography before (T0) and at 7 months (T1) after the surgical procedure. Bone graft resorption was measured clinically from a landmark screw head using a periodontal probe. The results were analyzed by Student’s t-test. Significant differences existed in the bone formation values at T0 and T1, with an average change of 4.03 ± 1.69 mm. Bone graft resorption values were 1.0 ± 0.82 mm (20%). Implants were placed with varying insertion torque values (35–45 Ncm), and achieved primary stability. This study demonstrates that FHBAs promote satisfactory vertical bone formation with a low resorption rates, good density, and primary implant stability.


Dental implants Transplantation Allograft Bone bank Bone Fresh frozen graft 


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Luis Guilherme Scavone Macedo
    • 1
  • Luiz Antonio Mazzucchelli-Cosmo
    • 2
  • Nelson Luiz Macedo
    • 3
    Email author
  • Adriana Socorro Ferreira Monteiro
    • 4
  • Wilson Roberto Sendyk
    • 5
  1. 1.Department of Dental Materials and ProsthesisSão Paulo State University, UNESPSão PauloBrazil
  2. 2.Periodontics and ImplantologySão PauloBrazil
  3. 3.Department of Diagnosis and Surgery, Periodontics DivisionSão Paulo State University, UNESPSão PauloBrazil
  4. 4.Bioscience Center for Special Health Care Needs (CEBAPE)São Paulo State University, UNESPSão PauloBrazil
  5. 5.Periodontics and Implantology, UNISASanto Amaro Dental SchoolSão PauloBrazil

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