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Cell and Tissue Banking

, Volume 13, Issue 2, pp 203–215 | Cite as

Historical perspectives and the future of adverse reactions associated with haemopoietic stem cells cryopreserved with dimethyl sulfoxide

  • Michael A. Cox
  • Jens Kastrup
  • Mikulas Hrubiško
Article

Abstract

A retrospective review of the published literature identified several hundred adverse reactions (e.g. nausea, chills, cardiac arrhythmias, neurological symptoms and respiratory arrest) associated with the transplantation of stem cells cryopreserved with dimethyl sulfoxide. The occurrences of these are generally accepted as commonplace, as the majority of reactions are transient, whilst a few patients may require clinical treatment. This exploratory study is a collation of the historical data and the expectations for the notification of serious adverse reactions. Outline information is presented on the development of related European Directives, some technical aspects of dimethyl sulfoxide and the sequential stages of preservation and administration.

Keywords

Dimethyl sulfoxide Adverse reactions Stem cells Transplantation Toxicity 

Notes

Acknowledgments

We would like to acknowledge the informative suggestions and scientific input by the late Dr Alan H. Cox. The authors also appreciate the technical and editorial review of earlier drafts by Joachim R. Karlsen and Charlotte Henriksen of the Danish Medicines Agency.

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Michael A. Cox
    • 1
  • Jens Kastrup
    • 2
  • Mikulas Hrubiško
    • 3
  1. 1.Danish Medicines AgencyCopenhagen SDenmark
  2. 2.Department of CardiologyRigshospital Copenhagen University HospitalCopenhagen ØDenmark
  3. 3.Slovak Medical UniversityBratislavaSlovakia

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