Modeling of intracellular processes using active charged particles
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A new method to model intracellular reactions coordinated by proteins is discussed. Proteins are described using locally interacting charged particles. The interaction is defined algorithmically, which allows disregarding the physical nature of protein activity in the analysis of the processes. Based on the proposed approach, a modeling software environment was developed and used as an example to analyze the process of formation of the hydrophobic core of a protein globule in water.
Keywordsmultiagent systems cellular automata Markov chain reactions of cellular metabolism protein
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- 1.Yu. M. Romanovskii and A. N. Tikhonov, “Molecular transformers of living cell energy. Proton ATF-synthase — rotating molecular motor,” Uspekhi Fiz. Nauk, No. 9, 931–956 (2010).Google Scholar
- 2.J. L. Casti, “Confronting science’s logical limits,” Scientific American, October, 78–81 (1996).Google Scholar
- 4.A. N. Shiryaev, Probability [in Russian], Nauka, Moscow (1980).Google Scholar
- 5.N. Metropolis, A. W. Rosenbluth, M. N. Rosenbluth, A. H. Teller, and E. Teller, “Equations of state calculations by fast computing machines,” J. of Chemical Physics, No. 6, 1087–1092 (1953).Google Scholar
- 6.W. K. Hastings, “Monte Carlo sampling methods using Markov chains and their applications,” Biometrika, No. 1, 97–109 (1970).Google Scholar
- 7.K. A. Dill, “Theory for the folding and stability of globular proteins,” Biochemistry, No. 6, 1501–1509 (1985).Google Scholar