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Cybernetics and Systems Analysis

, Volume 42, Issue 4, pp 483–495 | Cite as

A feedback control systems view of epileptic seizures

  • K. Tsakalis
  • N. Chakravarthy
  • Sh. Sabesan
  • L. D. Iasemidis
  • P. M. Pardalos
Article

Abstract

To understand basic functional mechanisms that cause epileptic seizures, the paper discusses some key features of theoretical brain functioning models. The hypothesis is put forward that a plausible reason for seizures is pathological feedback in brain circuitry. The analysis of such circuitry has an interesting physical interpretation and may be used to cure epilepsy.

Keywords

feedback control system epileptic seizure coupled-oscillator model 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • K. Tsakalis
    • 1
  • N. Chakravarthy
    • 1
  • Sh. Sabesan
    • 1
  • L. D. Iasemidis
    • 2
  • P. M. Pardalos
    • 3
  1. 1.Department of Electrical EngineeringArizona State UniversityUSA
  2. 2.Harrington Department of BioengineeringArizona State UniversityUSA
  3. 3.Department of Industrial and Systems Engineering, Department of Biomedical Engineering and McKnight Brain InstituteUniversity of FloridaUSA

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