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Cardiovascular Engineering

, Volume 7, Issue 2, pp 81–88 | Cite as

Cardiovascular Simulation Toolbox

  • Liron Sheffer
  • William P. Santamore
  • Ofer Barnea
Original Paper

Abstract

A toolbox for Matlab Simulink (trademark of Mathworks corp. etc.) was developed to simulate various models of flow in the cardiovascular system and study effects of different pathological conditions. The toolbox was based on well-known analog lumped models of blood flow in vessels, the varying elastance heart model, blood flow through vessels, shunts, and valves as well as models of oxygen exchange at lungs and tissue. The toolbox is modular providing the basic building blocks of the cardiovascular system. Parameters for the individual components may be set by the user to adapt the component to the simulated system. Several examples are shown. This modeling system is described and is also available for downloading as an open source for free use. The authors see this as the basis for wide collaboration and standardization in modeling. A web site will be available for accepting contributions from other researchers and to create a free exchange.

Keywords

Cardiovascular system Computer simulation Congenital cardiac malformation 

References

  1. Barnea O, et al. Computer simulation of mechanically-assisted failing canine circulation. Annals of Biomed Eng 1990;18:263–83CrossRefGoogle Scholar
  2. Barnea O. A blood vessel model based on velocity profiles. Comput Biol Med 1993;23(4):295–300, (3)PubMedCrossRefGoogle Scholar
  3. Barnea O, et al. Estimation of oxygen delivery in newborns with a univentricular circulation. Circulation 1998;98:1407–13PubMedGoogle Scholar
  4. Barnea O, Sheffer N. A computer model for analysis of fluid resuscitation. Comput Biol Med 1993;23:443–54PubMedCrossRefGoogle Scholar
  5. Berne RM, Levy MN. Cardiovascular physiology. 7th ed. Mosby:Year Book; 1997Google Scholar
  6. Beyar R, Seideman S. A Computer study of the left ventricular performance based on fiber structure, sarcomere dynamics, and transmural Electrical Propagation Velocity. Circ Res 1984;55:358PubMedGoogle Scholar
  7. Dittmer DS, Altman PL. Respiration and circulation. Bethesda, MD.: Federation of American Societies for experimental biology; 1971Google Scholar
  8. Forfar JO, Arneil GC. Text book of pediatrics. 3rd ed. Edinburgh: Curchill Livingstone; 1984 Google Scholar
  9. Fung YC. Biomechanics circulation. 2nd ed. Springer; 1997Google Scholar
  10. Garson A. et al., The science and practice of pediatrics cardiology Vol. I, Lea & Febiger; 1990Google Scholar
  11. Ishide N, et al. Effects of changes in the aortic input impedance on systolic pressure-ejected volume relationship in the isolated supported canine left ventricle. Cardiovasc Res 1980;14:229–43PubMedCrossRefGoogle Scholar
  12. Maughan WL, et al. Instantaneous pressure-volume relationship of canine right ventricle. Circ Res 1979;44:309–15PubMedGoogle Scholar
  13. McCulloch AD, Mazhari R. Regional myocardial mechanics: integrative computational models of flow-function relations. J Nucl Cardiol 2001;8(4):506–19PubMedCrossRefGoogle Scholar
  14. Rudolph AM. Fetal and Neonatal pulmonary circulation, Ann. Rev Physiol 1979;41:385–95CrossRefGoogle Scholar
  15. Senzaki H. Single beat estimation of end-systolic pressure-volume relation in humans. Circulation 1996;94:2497–506PubMedGoogle Scholar
  16. Suga H, Sagawa K. Instantaneous pressure-volume relationships and their ratio in excised, supported canine left ventricle, Circ. Res 1974;35:117–26Google Scholar
  17. Walker AL. Fetal and neonatal cardiology, W.B. Saunders Comp.; 1990Google Scholar
  18. Xiao X. Model based assessment of cardiovascular health from noninvasive measurements. Ann Biomed Eng 2002;30:612–23PubMedCrossRefGoogle Scholar
  19. Ziegler RF. Electrocardiographic studies in normal infants and children, C.C. Thomas, Springfield; 1951Google Scholar

Web sites

  1. http://www.hypertextbook.com/facts/2004/MichaelShmukler.shtmlGoogle Scholar
  2. http://www.ventworld.com/resources/oxydisso/dissoc.htmlGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Liron Sheffer
    • 1
  • William P. Santamore
    • 2
  • Ofer Barnea
    • 1
  1. 1.Biomedical Engineering Department, Faculty of EngineeringTel-Aviv UniversityRamat AvivIsrael
  2. 2.Division of Cardiovascular ResearchCardiology Section, Temple UniversityPhiladelphiaUSA

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