Cardiovascular Engineering

, Volume 7, Issue 2, pp 81–88 | Cite as

Cardiovascular Simulation Toolbox

  • Liron Sheffer
  • William P. Santamore
  • Ofer Barnea
Original Paper


A toolbox for Matlab Simulink (trademark of Mathworks corp. etc.) was developed to simulate various models of flow in the cardiovascular system and study effects of different pathological conditions. The toolbox was based on well-known analog lumped models of blood flow in vessels, the varying elastance heart model, blood flow through vessels, shunts, and valves as well as models of oxygen exchange at lungs and tissue. The toolbox is modular providing the basic building blocks of the cardiovascular system. Parameters for the individual components may be set by the user to adapt the component to the simulated system. Several examples are shown. This modeling system is described and is also available for downloading as an open source for free use. The authors see this as the basis for wide collaboration and standardization in modeling. A web site will be available for accepting contributions from other researchers and to create a free exchange.


Cardiovascular system Computer simulation Congenital cardiac malformation 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Liron Sheffer
    • 1
  • William P. Santamore
    • 2
  • Ofer Barnea
    • 1
  1. 1.Biomedical Engineering Department, Faculty of EngineeringTel-Aviv UniversityRamat AvivIsrael
  2. 2.Division of Cardiovascular ResearchCardiology Section, Temple UniversityPhiladelphiaUSA

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