Cardiovascular Drugs and Therapy

, Volume 32, Issue 2, pp 223–232 | Cite as

Old Drugs for New Indications in Cardiovascular Medicine

  • Yaron Arbel
  • Wael Abuzeid
  • Robert S Rosenson
  • Alanna Weisman
  • Michael E. Farkouh


Inflammation participates in the initiation and progression of atherosclerotic cardiovascular disease, and it is a critical inciting factor leading to acute ischemic events. Evidence has shown that certain anti-inflammatory medications used to treat non-atherosclerotic inflammatory diseases reduce cardiovascular events. This article reviews evidence that commonly used anti-inflammatory therapies (colchicine, allopurinol, methotrexate), reduce cardiovascular events. We discuss potential mechanisms of action, efficacy, and safety of these therapies and propose a clinical trials design to investigate their efficacy.


Colchicine Allopurinol Inflammation Methotrexate Atherosclerosis Cardiovascular disease 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

This article does not contain any studies with animals performed by any of the authors. This article does not contain any studies with human participants or animals performed by any of the authors.

Financial Disclosures

Robert S. Rosenson—Research Grant, Akcea, Amgen, Astra Zeneca, Medicines Company, Regeneron; Honoraria, Akcea, Kowa, Pfizer; Consultant/Advisory Board, Amgen, C5, CVS Caremark, Easy Vitals, Regeneron, Sanofi; Stock holdings, MediMergent; Royalties, UpToDate

Yaron Arbel—none to declare

Michael E. Farkouh—none to declare

Wael Abuzeid—none to declare

Alanna Weisman—none to declare


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Authors and Affiliations

  1. 1.Department of Cardiology, Tel Aviv Medical Center, Tel Aviv, affiliated to the Sackler School of MedicineTel Aviv UniversityTel AvivIsrael
  2. 2.Schulich Heart Centre, Division of CardiologySunnybrook Health Sciences Centre, Ontario, Canada, affiliated with the University of TorontoTorontoCanada
  3. 3.Mount Sinai Icahn School of MedicineMount Sinai HospitalNew YorkUSA
  4. 4.Division of Endocrinology & Metabolism, Department of MedicineUniversity of TorontoTorontoCanada
  5. 5.Peter Munk Centre, Heart & Stroke Richard Lewar Centre of ExcellenceUniversity of TorontoTorontoCanada

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