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Benefits and Difficulties in Measuring HDL Subfractions and Human Paraoxonase-1 Activity During Statin Treatment

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Abstract

Dyslipidaemia including decreased high density lipoprotein cholesterol concentration is one of several factors that have been implicated in increased cardiovascular risk. Since their introduction in the 1980s, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have emerged as the one of the best-selling class of medications to date, with numerous trials demonstrating powerful efficacy in preventing cardiovascular diseases. Although statins have been shown to modestly raise or not alter HDL-cholesterol, their effect on HDL subfractions and on HDL-associated enzymes including human paraoxonase-1 (PON1) has not yet been fully explored. This review summarizes the currently availabe data on the effect of statins on HDL subfractions and on PON1 activity with a particular emphasis on the clinical relevance of these effects. Moreover, methodological problems of HDL subfraction and PON1 activity determinations are also discussed.

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Authors and Affiliations

  1. First Department of Medicine, Medical and Health Sciences Center, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary

    Mariann Harangi, Ildikó Seres & György Paragh

  2. Research Laboratory for Chromatography, Polinszky Str. 17, 4032, Debrecen, Hungary

    János Harangi

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  1. Mariann Harangi
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  2. Ildikó Seres
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  3. János Harangi
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  4. György Paragh
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Correspondence to György Paragh.

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Harangi, M., Seres, I., Harangi, J. et al. Benefits and Difficulties in Measuring HDL Subfractions and Human Paraoxonase-1 Activity During Statin Treatment. Cardiovasc Drugs Ther 23, 501–510 (2009). https://doi.org/10.1007/s10557-009-6205-4

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  • DOI: https://doi.org/10.1007/s10557-009-6205-4

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