Cancer and Metastasis Reviews

, Volume 34, Issue 3, pp 443–464 | Cite as

New advances in genitourinary cancer: evidence gathered in 2014

  • C. Suárez
  • J. Puente
  • E. Gallardo
  • M. J. Méndez-Vidal
  • M. A. Climent
  • L. León
  • D. Olmos
  • X. García del Muro
  • E. González-Billalabeitia
  • E. Grande
  • J. Bellmunt
  • B. Mellado
  • P. Maroto
  • A. González del Alba


This review provides updated information published in 2014 regarding advances and major achievements in genitourinary cancer. Sections include the best in prostate cancer, renal cancer, bladder cancer, and germ cell tumors. In the field of prostate cancer, data related to treatment approach of hormone-sensitive disease, castrate-resistant prostate cancer, mechanisms of resistance, new drugs, and molecular research are presented. In relation to renal cancer, relevant aspects in the treatment of advanced renal cell carcinoma, immunotherapy, and molecular research, including angiogenesis and von Hippel-Lindau gene, molecular biology of non-clear cell histologies, and epigenetics of clear renal cell cancer are described. New strategies in the management of muscle-invasive localized bladder cancer and metastatic disease are reported as well as salient findings of biomolecular research in urothelial cancer. Some approaches intended to improve outcomes in poor prognosis patients with metastatic germ cell cancer are also reported. Results of clinical trials in these areas are discussed.


Genitourinary cancer Bladder cancer Renal cancer Prostate cancer Molecular research Germ cell tumors 



The authors thank Marta Pulido, MD, PhD, freelance author’s editor for assistance in writing of the manuscript and Content Ed Net Communications, Madrid (Spain) for editorial assistance with funding from Astellas.

Conflict of interest

C. Suárez has participated in advisory boards for Janssen, Astellas, Sanofi, and Bayer.

J. Puente has participated in advisory boards for Astellas, Sanofi, and Janssen.

E. Gallardo has been a member of advisory boards for Astellas, Janssen, Sanofi, and Bayer and has received travel or meeting funding by Astellas, Janssen, and Sanofi.

M.J. Méndez-Vidal has served as an advisor and a speaker for Janssen, Astellas, and Sanofi.

L. León has received honoraria as a speaker from Astellas.

D. Olmos have received research funding from Astellas, Janssen, Sanofi, Bayer, and Veridex.

X. García del Muro has served as an advisor and a speaker for Pfizer, Bayer, and Novartis.

E. González-Billalabeitia has been a member of the advisory boards of Astellas, Janssen, and Sanofi at the time of writing of the manuscript.

E. Grande has received financial support for research from Astellas, GSK, and Pfizer and served as an advisor and a speaker for Pfizer, Novartis, Pierre-Fabre, and Janssen.

A. González del Alba has participated in advisory boards for Janssen, Astellas, Sanofi, GSK and Bayer at the time of writing of the manuscript.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • C. Suárez
    • 1
  • J. Puente
    • 2
  • E. Gallardo
    • 3
  • M. J. Méndez-Vidal
    • 4
  • M. A. Climent
    • 5
  • L. León
    • 6
  • D. Olmos
    • 7
    • 8
    • 9
  • X. García del Muro
    • 10
  • E. González-Billalabeitia
    • 11
  • E. Grande
    • 12
  • J. Bellmunt
    • 13
  • B. Mellado
    • 14
  • P. Maroto
    • 15
  • A. González del Alba
    • 16
  1. 1.Vall d’Hebron University Hospital and Institute of OncologyUniversitat Autònoma de BarcelonaBarcelonaSpain
  2. 2.Medical Oncology DepartmentHospital Clínico Universitario San CarlosMadridSpain
  3. 3.Medical Oncology DepartmentHospital Universitari Parc TaulíBarcelonaSpain
  4. 4.Medical Oncology Department, Instituto Maimónides de Investigación Biomédica (IMIBIC)Hospital Universitario Reina SofíaCórdobaSpain
  5. 5.Medical Oncology DepartmentFundación Instituto Valenciano de OncologíaValenciaSpain
  6. 6.Medical Oncology DepartmentHospital ClínicoSantiago de CompostelaSpain
  7. 7.Prostate Cancer Clinical Research UnitSpanish National Cancer Research Centre (CNIO)MadridSpain
  8. 8.CNIO-IBIMA Genitourinary Cancer Research UnitHospitales Universitarios Virgen de la Victoria & Regional de MálagaMadridSpain
  9. 9.Centro Integral Oncológico Clara CampalMadridSpain
  10. 10.Institut Català d’Oncologia L’HospitaletBarcelonaSpain
  11. 11.Medical Oncology and Hematology DepartmentHospital G. U. Morales MeseguerMurciaSpain
  12. 12.Medical Oncology Department, GI, Endocrine and Translational Research Unit, Early Drug Development Unit-IRYCISRamon y Cajal University HospitalMadridSpain
  13. 13.Bladder Cancer Center, Dana-Farber Cancer Institute, Dana-Farber/Brigham and Women’s Cancer CenterHarvard Medical SchoolBostonUSA
  14. 14.Medical Oncology DepartmentHospital ClinicBarcelonaSpain
  15. 15.Medical Oncology DepartmentHospital de la Santa Creu i Sant PauBarcelonaSpain
  16. 16.Medical Oncology DepartmentHospital Universitario Son EspasesPalma de MallorcaSpain

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