Cancer and Metastasis Reviews

, Volume 33, Issue 4, pp 921–928 | Cite as

Role of MTA2 in human cancer

  • Kyle R. Covington
  • Suzanne A. W. Fuqua


Metastasis is the ultimate cause of death for most cancer patients. While many mechanisms have been delineated for regulation of growth and tumor initiation of the primary tumor, very little is known about the process of metastasis. Metastasis requires dynamic alteration of cellular processes in order for cells to disseminate from the primary tumor to distant sites. These alterations often involve dramatic changes in the regulation of cytoskeletal and cell-environment interactions. Furthermore, controlled refinement of these interactions requires feedback to regulatory networks in the nucleus. MTA2 is a member of the metastasis tumor-associated family of transcriptional regulators and is a central component of the nucleosome remodeling and histone deacetylation complex. MTA2 acts as a central hub for cytoskeletal organization and transcription and provides a link between nuclear and cytoskeletal organization. We will focus on MTA2 in this chapter, especially its role in breast cancer metastasis.


Metastasis-associated protein MTA2 Metastasis Breast cancer Tumor progression 



SAWF is supported by NIH/NCI R01 CA72038 and P30 CA125123-05, CPRIT RP120732-P7, and the Susan G. Komen Foundation PG12221410.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Lester and Sue Smith Breast Center, One Baylor PlazaBaylor College of MedicineHoustonUSA

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