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Cancer and Metastasis Reviews

, Volume 32, Issue 1–2, pp 109–122 | Cite as

Modeling prostate cancer in mice: something old, something new, something premalignant, something metastatic

  • Shazia Irshad
  • Cory Abate-Shen
Article

Abstract

More than 15 years ago, the first generation of genetically engineered mouse (GEM) models of prostate cancer was introduced. These transgenic models utilized prostate-specific promoters to express SV40 oncogenes specifically in prostate epithelium. Since the description of these initial models, there have been a plethora of GEM models of prostate cancer representing various perturbations of oncogenes or tumor suppressors, either alone or in combination. This review describes these GEM models, focusing on their relevance for human prostate cancer and highlighting their strengths and limitations, as well as opportunities for the future.

Keywords

Prostate cancer Genetically engineered mice GEM models 

Notes

Acknowledgments

We thank our colleagues in the NCI mouse models of human cancer consortium and the community of researchers who have been developing prostate cancer mouse models whose research have inspired us over the years. We are grateful to Drs. Robert Matusik, Michael Shen, Chee Wai Chua, Alvaro Aytes, and Takashi Kobayashi for comments on the manuscript. Research in the CAS laboratory is supported in part by NIH grants (CA084294, CA141535, and CA154293), the T.J. Martell Foundation for Leukemia, Cancer and AIDS Research, and the V-Foundation for Cancer Research. CAS is an American Cancer Society Research Professor supported in part by a generous gift from the F.M. Kirby Foundation.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Herbert Irving Comprehensive Cancer Center, Departments of Urology and Pathology & Cell BiologyColumbia University College of Physicians and SurgeonsNew YorkUSA
  2. 2.Herbert Irving Comprehensive Cancer CenterColumbia University College of Physicians and SurgeonsNew YorkUSA

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