Assessment of artery calcification in atherosclerosis with dynamic 18F-FDG-PET/CT imaging in elderly subjects
- 147 Downloads
Glucose metabolism in atherosclerotic arteries has been shown to be an indicator of inflammation, which might be a precursor of plaque rupture. In this prospective study, we assessed the correlation between artery calcification and glucose metabolism by means of 18F-FDG PET/CT imaging in elderly subjects. Nineteen elderly subjects, with age ranging from 65 to 85 years, underwent CT and dynamic 18F-FDG-PET imaging. The artery calcification was determined with a threshold of 130 Hounsfield units. Intensity of calcification and ratio of calcification area to total artery area were classified in four sequential classes from CT images. The CT artery images were also classified as having single or multi-spot calcifications. Their respective glucose metabolism was assessed with fractional uptake rate (FUR). Factor analysis was used in this study to separate blood images from tissue to extract the blood time activity curves for FUR calculations. The artery images in PET data were corrected for partial volume effect. The total arterial segments analyzed were 1332, with 1085 without calcification (81%), 247 (19%) with calcification, and 94 segments were having multi-spot of calcifications. There was a statistically significant difference in FUR values between non-calcified to calcified segments and between subjects under medication to non-medication when comparing the subjects based on calcification area. No statistically significant differences of FUR were found between single spot as a function of intensity, while in the multi-spots, there was a statistically significant difference for all artery segments. Metabolism activity varies for non-calcified to calcified segments. Based on the metabolic activity represented by FUR, calcifications in multi-spots have different effects than in single spots.
KeywordsAtherosclerosis Calcification Arteries Plaque PET PET/CT 18F-FDG
We are grateful to the Canadian Institutes of Health Research (CIHR) for their financial support, and to the Saudi Arabian culture bureau in Canada and University of Hail in kingdom of Saudi Arabia for the fellowship to Mr. Al-enezi.
Compliance with ethical standards
Conflict of interest
There are no conflict of interest.
- 6.Nighoghossian N, Derex L, Douek P (2005) The vulnerable carotid artery plaque: current imaging methods and new perspectives. Stroke 36:2764–2772. https://doi.org/10.1161/01.STR.0000190895.51934.43 CrossRefPubMedGoogle Scholar
- 7.Pugliese G, Iacobini C, Fantauzzi CB, Menini S (2015) The dark and bright side of atherosclerotic calcification. Atherosclerosis 238:220–230. https://doi.org/10.1016/j.atherosclerosis.2014.12.011 CrossRefPubMedGoogle Scholar
- 14.Izquierdo-Garcia D, Davies JR, Graves MJ et al (2009) Comparison of methods for magnetic resonance-guided [18-F]fluorodeoxyglucose positron emission tomography in human carotid arteries: reproducibility, partial volume correction, and correlation between methods. Stroke. 40(1):86–93. https://doi.org/10.1161/STROKEAHA.108.521393 CrossRefGoogle Scholar
- 21.Rudd JH, Myers KS, Bansilal S et al (2007) (18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: implications for atherosclerosis therapy trials. J Am Coll Cardiol 50:892–896. https://doi.org/10.1016/j.jacc.2007.05.024 CrossRefPubMedGoogle Scholar
- 22.Kitagawa T, Yamamoto H, Toshimitsu S et al (2017) 18F-sodium fluoride positron emission tomography for molecular imaging of coronary atherosclerosis based on computed tomography analysis. Atherosclerosis 263:385–392. https://doi.org/10.1016/j.atherosclerosis.2017.04.024 CrossRefGoogle Scholar
- 29.Croteau E, Lavallée É, Labbe SM et al (2010) Image-derived input function in dynamic human PET/CT: methodology and validation with 11C-acetate and 18F-fluorothioheptadecanoic acid in muscle and 18F-fluorodeoxyglucose in brain. Eur J Nucl Med Mol Imaging 37:1539–1550. https://doi.org/10.1007/s00259-010-1443-z CrossRefPubMedPubMedCentralGoogle Scholar
- 36.Kwee RM, Teule GJ, van Oostenbrugge RJ et al (2009) Multimodality imaging of carotid artery plaques: 18F-fluoro-2-deoxyglucose positron emission tomography, computed tomography, and magnetic resonance imaging. Stroke 40:3718–3724. https://doi.org/10.1161/strokeaha.109.564088 CrossRefPubMedGoogle Scholar